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Letter to the Editor

Clozapine in the Treatment of Aggression in an Adolescent With Autistic Disorder

Neal C. Chen, Hany S. Bedair, Bernice McKay, Malcolm B. Bowers, Jr., and Carolyn Mazure

Published: June 1, 2001

Article Abstract

Letter to the Editor

Sir: The pharmacotherapy of autism and pervasive developmental disorders primarily targets central serotonin or dopamine pathways. The use of haloperidol in treating autism in children was well studied in several double-blind, placebocontrolled studies by Campbell and associates. In addition, a double-blind, placebo-controlled study by McDougle et al. showed that the selective serotonin reuptake inhibitor (SSRI) fluvoxamine reduced repetitive thoughts and behavior, maladaptive behavior, and aggression in adults with autistic disorder.

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