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Letter to the Editor

Coadministration of Isoniazid and Antidepressant Drugs

Parviz Malek-Ahmadi, MD; Marina Chavez, MD; and Salvador A. Contreras, MD

Published: November 15, 1996

Article Abstract

Letter to the Editor

Sir: Isonicotinylhydrazide, also known as isoniazid, is awell-known agent for treatment of mycobacterial infections. Itis also used for prevention of tuberculosis, given 300 mg/dayfor a period of at least 6 months. In vivo studies, usingbenzylamine as substrate, have demonstrated that isoniazid intherapeutic doses inhibits plasma monoamine oxidase (MAO)with no significant effect on platelet MAO.

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