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The Journal of
Clinical Psychiatry
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The Journal of Clinical Psychiatry

Letter to the Editor February 28, 1999

Early Augmentation of Sertraline With Methylphenidate

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J Clin Psychiatry 1999;60(2):123-124

Article Abstract

Letter to the Editor

Sir: Augmentation of ineffective or partially effective selective serotonin reuptake inhibitors (SSRIs) with methylphenidate appears to be empirically rapid, safe, and efficacious. It had been speculated that stimulants might not only augment SSRIs, but might also shorten the response latency to SSRIs if coadministered early in the course of treatment. No controlled studies on the efficacy of an early combination of an SSRI and a stimulant have been previously reported.

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