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Letter to the Editor

Gender Imbalance in Clinical Trials in Schizophrenia

Sonia Villero, MD, and David Fraguas, MD

Published: March 14, 2008

Article Abstract

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Sir: A recent study on the prevalence of schizophrenia inthe general population using a structured clinical interviewevidenced no sex difference in lifetime prevalence: 0.82%(95% CI = 0.56 to 1.19) for men and 0.91% (0.65 to 1.27) forwomen.1 These figures are in agreement with a review of 1721prevalence estimates of schizophrenia from 188 epidemiologicallyheterogeneous studies (published between 1965 and2002) showing no significant differences between genders.2Our own records from Puente de Vallecas Health Center inMadrid, Spain, which is the referral mental health center forapproximately 250,000 inhabitants, showed a male/female ratioof 1.33 among the 1104 patients who received a diagnosisof schizophrenia (based on ICD-9 criteria) between 1990 and2005.’ ‹

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