This work may not be copied, distributed, displayed, published, reproduced, transmitted, modified, posted, sold, licensed, or used for commercial purposes. By downloading this file, you are agreeing to the publisher’s Terms & Conditions.

Letter to the Editor

High-Dose Olanzapine Versus Clozapine

Jeffrey A. Mattes, MD

Published: October 31, 2008

Article Abstract

Because this piece has no abstract, we have provided for your benefit the first 3 sentences of the full text.

Sir: The article by Meltzer and colleagues1 suggestingthat high-dose olanzapine may be equivalent to clozapine intreatment-resistant schizophrenics warrants some discussion.

The authors’ power analysis suggested that 17 patients pergroup would be sufficient to provide 80% power. However, thepower analysis (as is often the case) did not consider dropouts,and this was a particular concern in this study since 6 of 21 patientsreceiving clozapine dropped out prior to 6 weeks.’ ‹

Some JCP and PCC articles are available in PDF format only. Please click the PDF link at the top of this page to access the full text.

Related Articles

Volume: 69

Quick Links: