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Letter to the Editor

Interactions of Cyclobenzaprine and Tricyclic Antidepressants

Nicholas Z. Rosenlicht, MD, and Kristin P. Riley-Lazo, MD

Published: January 15, 2005

Article Abstract

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Sir: Cyclobenzaprine, a tricyclic compound, is closely related to the tricyclic antidepressants. Structurally, it differs from amitriptyline only by 1 double bond. It is classified as a muscle relaxant and is used frequently in primary care settings to treat musculoskeletal pain, sometimes in combination with tricyclic antidepressants.’ ‹’ ‹’ ‹’ ‹

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