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Letter to the Editor

Is Clozapine Safe in Patients With Preexisting Epilepsy? A Report of 2 Cases

James T. Antony, MD, MRCPsych; Alby Elias, MD; Fiju Chacko, MD, DM; and Biju Rajan, MRCPsych

Published: February 14, 2008

Article Abstract

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Sir: Clozapine is associated with seizures in 2% to 3% ofpatients who receive it.1,2 This risk increases when patients havepreexisting neurologic abnormalities.2 Langosch and Trimblehave described the use of clozapine in the treatment of psychosisin patients with epilepsy.3‘ ‹

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