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Letter to the Editor

Lamotrigine as Prophylaxis Against Steroid-Induced Mania

Adrian Preda, Amin Fazeli, Bernice G. McKay, Malcolm B. Bowers, Jr., and Carolyn M. Mazure

Published: October 31, 1999

Article Abstract

Letter to the Editor

Sir: Corticosteroid therapy, used to treat a variety of inflammatory diseases, can cause severe mood changes and psychosis in a subgroup of patients. This case suggests that lamotrigine, a new anticonvulsive drug with mood-stabilizing effects, may prevent steroid-induced mania in patients for whom lithium or valproate treatment is not possible.

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