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Letter to the Editor

Manic and Psychotic Symptoms Following Risperidone Withdrawal in a Schizophrenic Patient

Hsien-Yuan Lane and Wen-Ho Chang

Published: November 15, 1998

Article Abstract

Sir: Risperidone, a serotonin-2/dopamine-2 (5HT2/D2) receptor antagonist, has been demonstrated to be effective in reducing both positive and negative symptoms of schizophrenia. Concerning its withdrawal-related symptoms, only akathisia and dyskinesia have been reported. In contrast, rapid discontinuation of clozapine, another atypical antipsychotic agent, could cause various symptoms including conscious disturbance, rebound psychosis, dyskinesia, motor restlessness, anxiety, insomnia, nausea, and diaphoresis.

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