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Letter to the Editor

Measurement of Pain and Medication Effect in a Study of Duloxetine

Jay M. Griffith, MD; Joseph P. Hasley, MA; and Daniel G. Severn, DO, MPA

Published: June 30, 2008

Article Abstract

Letter to the Editor

Sir: We would like to comment on the November 2007 articleby Brecht et al. that addressed the efficacy and safety ofduloxetine in treating pain in patients experiencing major depressivedisorder. We concur with the authors that co-occurringpain and depression is a clinical issue of utmost importance, onethat has only recently begun to gain a level of attention commensuratewith its clinical impact. However, we believe that anumber of issues potentially limit this investigation’s applicabilityto the clinical setting.

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