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Letter to the Editor

Nefazodone-Associated Subjective Complaints of Burning Sensations

Vladimir Lerner, Michael A. Matar, and Inessa Polyakova

Published: August 31, 2000

Article Abstract

Letter to the Editor


Nefazodone is a relatively new antidepressant drug.Preclinical data suggest that it has potent antagonistic effects onpostsynaptic serotonin-2 (5-HT2) receptors and moderate presynapticserotonin and norepinephrine reuptake inhibiting propertieswhile demonstrating low affinity for other receptor types(including other 5-HT receptors and cholinergic, a-adrenergic,dopaminergic, and histaminergic receptors). It has to date beenshown to be safe and well tolerated, with clinical efficacycomparable to that of selective serotonin reuptake inhibitors(SSRIs).

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