This work may not be copied, distributed, displayed, published, reproduced, transmitted, modified, posted, sold, licensed, or used for commercial purposes. By downloading this file, you are agreeing to the publisher’s Terms & Conditions.

Letter to the Editor

Omega-3 Fatty Acids Are More Beneficial in the Depressive Phase Than in the Manic Phase in Patients With Bipolar I Disorder.”

Chih-Chiang Chiu, MD; Shih-Yi Huang, PhD; Chiao-Chicy Chen, PhD; and Kuan-Pin, MD

Published: December 15, 2005

Article Abstract

Because this piece has no abstract, we have provided for your benefit the first 3 sentences of the full text.

Sir: We read with interest the recent (June 2005) report byOsher et al.1 that described the potential effectiveness of omega-3 polyunsaturated fatty acids (PUFAs) in the treatment of bipolardepression.1 In 1999, Stoll et al.2 found that adjunctivetreatment with omega-3 PUFAs had a mood-stabilizing effectin patients with bipolar disorder in their 4-month doubleblind,placebo-controlled study. In our reexamination of thedata reported by Stoll et al., we3 found that all "non-completed"cases (3 of 14 cases) in the omega-3 group developed a manicepisode, whereas the depressive symptoms in all but 1 of thenon-completed cases (10 of 16 cases), in the placebo groupworsened.’ ‹

Some JCP and PCC articles are available in PDF format only. Please click the PDF link at the top of this page to access the full text.

Volume: 66

Quick Links: