Empowering mental health professionals with peer-reviewed psychiatric research and insights
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Original Research
Klotho and Matrix Metalloproteinase-9 Levels and Their Association with Inhibitory Dyscontrol in Adolescents with First-Episode Major Affective Disorders
July 16, 2025
Adolescents with bipolar disorder and those with MDD had significantly lower Klotho levels compared with the control group; those with bipolar disorder had the highest MMP-9 levels, followed by…
Original Research
Actigraphy-Measured Sleep/Wake Characteristics Associated With Suicidal Ideation in Older Adults With Depression and High Suicide Risk
July 14, 2025
Measures of sleep/wake rhythm disruption were independently associated with higher level of suicidal ideation in this sample of older adults at high risk for suicide.
Original Research
Predictors of Treatment Response to Adjunctive VNS Therapy in Major Depressive Disorder: A RECOVER Trial Report
July 14, 2025
History of ECT use (lifetime and current episode) or TMS use (current episode) was prognostic of poorer outcomes across the total sample and superior benefit from active versus sham…
Vol 86 • 2025 • Number 2
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Original Research
Incidence and Risk Factors for Suicide Attempt During Pregnancy and Postpartum
Original Research
Valbenazine in Elderly Adults With Tardive Dyskinesia
Academic Highlights
Optimizing Treatment With Aripiprazole Monohydrate: Pharmacokinetic Advantages of Long-Acting Injectable Formulations, A Consensus Panel Report
Original Research
Older Adults Visiting Emergency Departments for Mental Health Issues:A CHIRPP Database Study
Consensus Statement
Developing a Treatment-Resistant Depression Consultation Program, Part I: Practical and Logistical Considerations
Brief Report
Psychosocial Correlates of Optimism among US Military Veterans
Original Research
Original Research
Global Population-Based Study on the Association Between Ketamine and Esketamine with Suicidality Using WHO VigiBase
July 7, 2025
The results do not provide causal evidence of worsening suicidality in persons receiving esketamine/ketamine; mixed results of increased and decreased risk of suicidality were reported with both agents.
Review Articles
Review Article
Cognitive Effects of ECT in Schizophrenia: A Review
June 5, 2024
ECT was not associated with any significant cognitive deficits in people with treatment-resistant schizophrenia across global cognition, attention, language, visuospatial function, and executive function domains. The majority of studies…
Read articles from ASCP Corner
Letters to the Editor
Letter to the Editor
Mental Health Assessment and Psychosocial Intervention in Maternal-Fetal Interventions
November 18, 2024
In discussing a recent JCP letter to the editor, Akerson et al recommend that centers for fetal diagnosis and treatment include a social worker who can provide psychosocial assessment,…
Commentaries
Commentary
Lower Risk of Cardiovascular Disorders in Antidepressant-Treated Women Veterans: Encouraging Findings but Concerns Remain
May 7, 2025
Comments on a study by Sumner et al that followed 609,546 women veterans for a mean of 8.8 years to look at associations of antidepressants with incident CVD.
Commentary
Eating Disorders Among Transgender and Gender Diverse People: Qualitative Analysis of Reddit Threads
March 10, 2025
This subreddit analysis characterizes the body dissatisfaction and desire to eliminate gendered physical characteristics that transgender and gender diverse (TGD) people with eating disorders experience. Many on the subreddit…
More JCP Articles
Clinical and Practical Psychopharmacology
A Primer on Individual Participant Data Meta-Analysis and Its Strengths and Limitations
July 7, 2025
This article discusses individual participant data meta-analysis, which differs from conventional meta-analysis in that the statistical team obtains and processes individual participant data from the source studies.
Original Research
Differentiating Subtypes of MDD Using Serum Biomarkers
June 23, 2025
Significant differences in biomarker profiles were observed across MDD subtypes: the melancholic subtype showed higher cortisol levels and lower serotonin levels, and the atypical subtype showed elevated levels of…
Original Research
Bright Light Therapy in the Morning or Midday for Nonseasonal Depression in Bipolar Disorder
June 23, 2025
Bright light therapy is well tolerated in bipolar disorder, starting at 45 minutes/day, with only 6% of patients experiencing a hypomanic switch and 13% experiencing subsyndromic symptoms, which resolved…
Original Research
Association Between Adult Sexual Assault and Psychiatric Disorders: Results From NESARC
June 16, 2025
Among participants who experienced adult sexual assault, 85.25% had at least 1 lifetime psychiatric disorder. In women, the strongest associations were with PTSD, borderline personality disorder, and suicide attempts,…
Clinical and Practical Psychopharmacology
Schizophrenia, Antipsychotic Drugs, and Risk of Breast Cancer
June 16, 2025
This article examines recent meta-analyses and observational studies on breast cancer risk in women with schizophrenia, especially in the context of treatment with first generation and second generation antipsychotics
Original Research
Cognitive Behavioral Therapy for Insomnia with Prolonged Exposure Compared to Sleep Hygiene and Prolonged Exposure
June 4, 2025
On average, participants had reductions in PTSD symptoms, with no differences between the treatment groups. CBT for insomnia with prolonged exposure produced greater reductions in insomnia symptoms and increases…
