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Letter to the Editor

Possible Increased Efficacy of Low-Dose Clozapine When Combined With Aripiprazole

Sabina Lim, MPH, MD; Catalin Pralea, MD; Jerome Schnitt, MD; Malcolm B. Bowers, Jr., MD

Published: September 1, 2004

Article Abstract

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Sir: Clozapine has been shown to be superior to typical antipsychotics in treatment-refractory schizophrenic patients. However, patients are sometimes unable to tolerate full therapeutic doses of clozapine because of significant adverse central nervous system and gastrointestinal effects at high doses. Aripiprazole is a new antipsychotic with a novel mechanism of action.

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Volume: 65

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