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Letter to the Editor

Reply to “Accurate Meta-Analytical Assesment of “True Antidepressants Effects”

Michael A. Posternak, MD, and Mark Zimmerman, MD

Published: September 15, 2005

Article Abstract

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Sir: We thank Dr. Quitkin and colleagues from ColumbiaUniversity for their comments regarding our article.1 As wepoint out in the article, the investigators from Columbia Universitywere the pioneers in advancing our understanding of thetiming of the antidepressant response. The findings from ourmeta-analysis, however, largely contradict their delayed antidepressantresponse theory, and Dr. Quitkin and colleagues rejectour findings after arguing that the meta-analysis we conductedwas "inappropriate."’ ‹’ ‹

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Volume: 66

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