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Letter to the Editor

Reply to Applying Parsimony to “An African Patient With Ziprasidone Intolerance”

Jakob Hein, MD

Published: November 15, 2005

Article Abstract

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Sir: Our letter is the first report of a dramatically increasedserum concentration of ziprasidone and the second report of theoccurrence of severe side effects with that same medication,both effects occurring despite a demonstrably normal dose ofthe drug. As it happens, both patients in question had an Africanethnic background.The great William of Occam suggested that "entities are notto be multiplied beyond necessity,"1 the principle that has becomeknown as "Occam’s razor."’ ‹

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Volume: 66

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