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Letter to the Editor

Reply to Letter to the Editor “Need for a New Framework to Understand the Mechanism of All Antipsychotics”

Gary J. Remington and Shitij Kapur

Published: October 31, 2000

Article Abstract

Letter to the Editor

Sir: We appreciate the comments by Stip and colleagues andwould like to respond to several issues they have raised.

They suggest that the notion of D2 occupancy thresholds forclinical response and extrapyramidal symptoms (EPS) (approximately60% and 80%, respectively) does not adequatelyaccount for that group of individuals who require higher antipsychoticdoses than what this model might predict. This is true.Certain individuals, albeit a small subgroup, appear to benefitfrom high-dose therapy, reminding us that existing theories arenot absolute.

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Volume: 61

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