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Letter to the Editor

Safety in Overdose of Quetiapine: A Case Report

Ellen Nudelman, Luis M. Vinuela, and Carl I. Cohen

Published: August 15, 1998

Article Abstract

Sir: Quetiapine (Seroquel) is a new atypical antipsychotic drug belonging to a new chemical class, the dibenzothiazepine derivatives. It is a serotonin and dopamine receptor antagonist, which also has antagonistic activity at α-adrenergic and histamine receptor sites. A MEDLINE review of the literature yielded no prior published reports of quetiapine overdosage. Therefore, we report the case of a patient who intentionally ingested a large quantity of quetiapine.

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