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Letter to the Editor

SSRI Optimal Dose Remains at Issue

Arthur Rifkin

Published: February 15, 1997

Article Abstract

Letter to the Editor

Sir: Drs. Gammon and Lane assert that Dr. Nemeroff erredwhen, in his review of drug treatment of depression, he saidthat most patients require more than 50 mg/day of sertraline, indistinction to other serotonin selective reuptake inhibitors,which require no more, usually, than the initial dosage: paroxetine20 mg/day and fluoxetine 20 mg/day. They even accuse Dr.Nemeroff of bias because his paper came from a presentationsupported by the makers of paroxetine. Dr. Nemeroff defendedhimself by referring to dose-response literature.

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