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Letter to the Editor

Transient Hyperproinsulinemia DuringTreatment With Clozapine and Amisulpride

Maria A. Rettenbacher, MD; Martina Hummer, MD; W. Wolfgang Fleischhacker, MD

Published: June 1, 2004

Article Abstract

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Sir: Impaired glucose metabolism may occur during treatment with second-generation antipsychotics, predominantly clozapine, olanzapine, and quetiapine.1,2 The mechanisms involved in this metabolic side effect of antipsychotic therapy seem to be complex and are a point of ongoing discussion, especially as they relate to the use of antipsychotic combination therapy in treatment-resistant patients.3

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Volume: 65

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