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Letter to the Editor

Treatment-Emergent Psychosis With Aripiprazole

Matthew E. Barnas, MD; Najeeb Hussain, MD; and Georgios Petrides, MD

Published: October 14, 2005

Article Abstract

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Sir: Aripiprazole, the latest atypical antipsychotic to receiveapproval by the U.S. Food and Drug Administration, is uniquein its action as a partial agonist at dopamine receptors.1 Partialagonists can function as net agonists or net antagonists, dependingon the amount of naturally occurring full agonist neurotransmitterthat is present. Aripiprazole has antagonist activityat dopamine-2 (D2) receptors in a hyperdopaminergic environmentand agonist activity in a hypodopaminergic environment.’ ‹

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Volume: 66

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