Research Methodology
Recently published articles about Research Methods and Statistics
Original Research
Lack of Generalizability of PTSD Treatment Trials: The Recent Brexpiprazole-Sertraline Trials as an Example
November 26, 2025
In an outpatient psychiatry sample, nearly 95% of patients who want treatment for PTSD would not have qualified for the trials of brexpiprazole-sertraline for PTSD.
Clinical and Practical Psychopharmacology
The Superiority of Clozapine Over SGAs in Patients With Treatment-Resistant Schizophrenia
August 25, 2025
Clozapine is associated with many adverse effects. Given the findings that olanzapine and risperidone may be as good as clozapine in treatment-resistant schizophrenia (TRS), it may be worth trialing...
Clinical and Practical Psychopharmacology
A Primer on Individual Participant Data Meta-Analysis and Its Strengths and Limitations
July 7, 2025
This article discusses individual participant data meta-analysis, which differs from conventional meta-analysis in that the statistical team obtains and processes individual participant data from the source studies.
Recent JCP Articles on Research Methods and Statistics
Clinical and Practical Psychopharmacology
Using Percentiles to Understand Standardized Mean Difference as a Measure of Effect Size
August 7, 2023
Chittaranjan Andrade, MD, explains the use of SMDs as a measure of effect size. A recent meta-analysis of the effect of ChEIs on hallucinations and delusions in Alzheimer and...
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Clinical and Practical Psychopharmacology
Target Trial Emulation: A Concept Simply Explained
February 12, 2025
Target trial emulation can address study objectives that, for ethical or logistic reasons, cannot easily be examined in RCTs. Read this article to learn about the methodology and explore...
Clinical and Practical Psychopharmacology
Understanding Meta-Analysis Using Gestational Exposure to Cannabis and Birth Defects
November 20, 2024
Dr Andrade discusses strengths and limitations of two recent meta-analyses on birth defects associated with cannabis exposure, with a view to providing readers with a deeper understanding of how...
Original Research
Comorbidity and Quality of Life in Social Anxiety Disorder
May 27, 2024
Depression, anxiety disorders, PTSD, and borderline personality disorder were associated with social anxiety disorder (SAD). Presence of these disorders was also associated with poorer mental health in those with...
