Research Methodology
Recently published articles about Research Methods and Statistics
Clinical and Practical Psychopharmacology
The Superiority of Clozapine Over SGAs in Patients With Treatment-Resistant Schizophrenia
August 25, 2025
Clozapine is associated with many adverse effects. Given the findings that olanzapine and risperidone may be as good as clozapine in treatment-resistant schizophrenia (TRS), it may be worth trialing...
Clinical and Practical Psychopharmacology
A Primer on Individual Participant Data Meta-Analysis and Its Strengths and Limitations
July 7, 2025
This article discusses individual participant data meta-analysis, which differs from conventional meta-analysis in that the statistical team obtains and processes individual participant data from the source studies.
Clinical and Practical Psychopharmacology
Target Trial Emulation: A Concept Simply Explained
February 12, 2025
Target trial emulation can address study objectives that, for ethical or logistic reasons, cannot easily be examined in RCTs. Read this article to learn about the methodology and explore...
Clinical and Practical Psychopharmacology
Understanding Meta-Analysis Using Gestational Exposure to Cannabis and Birth Defects
November 20, 2024
Dr Andrade discusses strengths and limitations of two recent meta-analyses on birth defects associated with cannabis exposure, with a view to providing readers with a deeper understanding of how...
Recent JCP Articles on Research Methods and Statistics
Original Research
Autoimmune Diseases, Treatments, and Dementia Risk: A Population-Based Case-Control Study from Taiwan
October 15, 2025
Thirteen autoimmune diseases were linked with an elevated dementia risk, particularly Behçet's disease, multiple sclerosis, and lupus. Associations with vascular dementia were stronger than with Alzheimer's disease.
Original Research
Brexpiprazole for the Treatment of Co-Occurring Schizophrenia and Substance Use Disorder
October 13, 2025
This pilot trial suggests that brexpiprazole might be beneficial in reducing substance craving and use and improve quality of life in this difficult-to-treat patient population.
