The potential side effects of psychiatric medications are a critical consideration in patient care. The Journal of Clinical Psychiatry is dedicated to providing clinicians with comprehensive insights into the adverse effects associated with various treatments. Our expert editors curate content that delves into the physiological and psychological impacts of medications, from weight gain and sedation to mood changes and cognitive disturbances. As the field of psychopharmacology continues to evolve, our journal remains a trusted resource for understanding the balance between therapeutic benefits and potential risks.

Recently published articles about Side Effects

PCC
Osmotic Demyelination Syndrome Presenting as EPS
Case Report

April 21, 2026

A 44-year-old woman was initially referred for presumed domperidone-induced extrapyramidal symptoms, but further workup uncovered a complex interplay of hyponatremia, demyelination, and neuroleptic hypersensitivity.
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PCC
Acitretin, Homocysteine, and Neuropsychiatric Symptoms
Case Report

April 14, 2026

This report describes a case of acitretin-associated hyperhomocysteinemia that induced neuropsychiatric symptoms in a patient with chronic plaque psoriasis, highlighting the need for monitoring.
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PCC
Dose-Dependent Valproic Acid–Induced Hyperkalemia
Case Report

April 9, 2026

The authors present the case of a young man with bradycardia and Jacobs syndrome, in which a clear, dose-dependent relationship between valproic acid and hyperkalemia was observed.
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JCP
Metformin for Prevention of Antipsychotic-Induced Weight Gain: The Optimal Strategy
Letter to the Editor

April 6, 2026

Dr Huang discusses the potential for B12 deficiency in patients coprescribed antipsychotics and metformin.
PCC
Between Crisis and Clarity: Steroid-Induced Psychosis in Addison Disease
Case Report

March 24, 2026

This case highlights a rare but clinically significant dilemma: balancing essential corticosteroid replacement against neuropsychiatric toxicity.
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PCC
Atypical Presentation of Autoimmune Encephalitis
Case Report

March 19, 2026

A 23-year-old woman presented with probable antibody-negative autoimmune encephalitis that initially mimicked a primary psychiatric disorder.
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Recent JCP Articles on Side Effects

JCP
Urological Commentary on Ketamine-Associated Uropathy
Letter to the Editor

January 26, 2026

The author comments on a recent article reviewing ketamine-associated uropathy in therapeutic and nontherapeutic settings.
JCP
Ketamine-Associated Uropathy in Therapeutic Contexts: Reply to Abdelrahman
Letter to the Editor

January 26, 2026

Dr Andrade responds to a letter commenting on his recent review of ketamine-associated uropathy in therapeutic and nontherapeutic settings.
JCP
Rechallenge of Lamotrigine After Rash: A Systematic Review
Systematic Review

December 31, 2025

Lamotrigine has been rechallenged safely in select cases, but it is critical to confirm that the initial rash did not have specific features of a severe rash in order...
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Recent PCC Articles on Side Effects

PCC
Intranasal Tapentadol Dependence
Case Report

February 26, 2026

The authors present 2 cases of intranasal tapentadol dependence marked by rapid tolerance and significant physical and psychological issues.
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PCC
Calcineurin Inhibitor–Induced Psychosis
Case Report

February 17, 2026

The authors report a case of delayed and recurrent calcineurin inhibitor–induced psychosis with both tacrolimus and cyclosporine, highlighting the need to better understand host vulnerability and risk stratification.
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PCC
Benign Ethnic Neutropenia and Clozapine
Case Report

January 22, 2026

This case highlights the importance of recognizing benign ethnic neutropenia to prevent unnecessary clozapine discontinuation.
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The latest news on Side Effects

Featured Side Effects Research

JCP
Severity of Antipsychotic-Induced Cervical Dystonia by Algorithm-Based Rating System
Original Research

April 15, 2024

Rater consensus data were compared with deviation angle data using AI-based deviation angle measurement technology. With the range of tilt angles found in the study, the authors propose a...
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JCP
Associations of Valproate Doses With Weight Gain in Psychiatric Patients
Original Research

March 27, 2024

Valproate dose increase of 500 mg was associated with a weight change of +0.52% per month over a year. No associations were found between valproate dose and blood glucose,...
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JCP
CYP2D6 Genotyping and Adverse Drug Reactions in Depression
Original Research

January 17, 2024

Genetic testing of CYP2D6 did not show that predicted poor drug metabolism led to increased adverse drug reactions in patients with depression.
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PCC
Recreational Ketamine-Induced Uropathy
Brief Report

March 19, 2026

Two patients with chronic recreational ketamine use presented with urinary frequency, urgency, dysuria, and hematuria in the absence of infection.
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JCP
Vitamin B12 Deficiency Risk With Metformin for Weight Management in Second-Generation Antipsychotic Recipients: Reply to Mulsant et al
Letter to the Editor

March 18, 2026

Daggolu and Chen reply to a letter commenting on their study of metformin use in patients receiving second-generation antipsychotics.
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JCP
Concurrent Metformin and Second-Generation Antipsychotics: The Need to Add Vitamin B12
Letter to the Editor

March 18, 2026

The authors recommend vigilance for potential B12 deficiency when coprescribing metformin and antipsychotics.
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PCC
Tacrolimus-Induced Parasomnia Posttransplantation
Case Report

March 17, 2026

The authors present a rare case of tacrolimus-induced parasomnia, adding to the body of evidence on its neurotoxic potential.
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PCC
Clozapine-Induced Antiphospholipid Syndrome
Case Report

March 12, 2026

A 68-year-old man with no pre‐existing risk factors experienced clozapine-induced antiphospholipid syndrome and a deep vein thrombosis.
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PCC
Caffeine for ICI Encephalitis
Case Report

March 5, 2026

With the increased use of immune checkpoint inhibitors, the potential for aseptic encephalitis poses a unique challenge to patient rehabilitation.
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