Case Report

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PCC
Zolpidem for Severe Insomnia Associated With Delirium in Critical Illness
Case Report

June 11, 2026

A critically ill patient with sepsis and persistent delirium with treatment-refractory insomnia experienced rapid improvement in sleep continuity, delirium severity, and bedside cognitive performance with zolpidem.
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PCC
Catatonia Induced by D2R Antagonist Antiemetics
Case Report

June 4, 2026

The authors describe a rare case of catatonia correlated with abuse of D2R antagonist antiemetic medications in a 52-year-old man with multiple sclerosis.
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PCC
Psychosis in Japanese Encephalitis
Case Report

June 2, 2026

This case underscores the importance of considering viral encephalitis as a differential diagnosis for acute neuropsychiatric presentations associated with fever, particularly in patients residing in endemic areas.
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PCC
Shared Possession Trance Disorder in 4 Children
Case Report

May 28, 2026

Four children from the same household experienced recurrent fainting episodes accompanied by changes in speech, facial expression, and mannerisms.
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PCC
Ventilation Weaning, Anxiety, and Valproic Acid
Case Report

May 28, 2026

The authors present the case of a man with Guillan Barre syndrome, whose mechanical ventilation weaning was prolonged, in part, by anxiety.
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PCC
Scrambler Therapy for Neuropathic Pain
Case Report

May 26, 2026

Scrambler therapy is an innovative treatment option for patients with chronic neuropathic pain, especially for those who do not respond to conventional interventions.
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Oral Glutamatergic Modulation with Dextromethorphan and Piracetam for Refractory Bipolar Disorder With OCD
Case Report

February 23, 2026

Three patients with combined bipolar disorder and OCD experienced remission of depressive, anxious, and obsessive-compulsive symptoms after piracetam was added to dextromethorphan.
JCP
Zuranolone for Postpartum Depression in Real-World Clinical Practice
Case Report

July 2, 2025

Three cases of successful treatment of postpartum depression with zuranolone are presented and discussed.
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JCP
Administering Semaglutide With Long-Term Olanzapine Use
Case Report

June 9, 2025

This report describes use of the GLP-1R agonist semaglutide in a patient with schizophrenia and severe, olanzapine-induced weight gain that was resistant to alternative treatments.
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Diphenhydramine and Dextromethorphan Overdose
Case Report

April 28, 2026

The authors describe a case of intentional overdose with diphenhydramine and extended-release dextromethorphan-guaifenesin that initially presented with anticholinergic toxicity and later evolved into serotonin toxicity.
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PCC
Psychotropic-Induced Reversible Cerebral Vasoconstriction Syndrome
Case Report

April 23, 2026

This case reinforces the importance of monitoring for acute neurologic symptoms in patients treated with high-dose selective serotonin reuptake inhibitors.
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PCC
Osmotic Demyelination Syndrome Presenting as EPS
Case Report

April 21, 2026

A 44-year-old woman was initially referred for presumed domperidone-induced extrapyramidal symptoms, but further workup uncovered a complex interplay of hyponatremia, demyelination, and neuroleptic hypersensitivity.
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Featured Case Report Research

JCP
Placebo Effects in Alcohol, Cocaine, and Methamphetamine Use Disorder
Meta-Analysis

June 10, 2026

Placebo treatment led to reductions in craving scores across all three disorders, although statistical significance was achieved only in alcohol use disorder.
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JCP
Hallucinogen–Psychosis Associations Are Confounded by Baseline Psychiatric History
Original Research ▶ Video

June 10, 2026

Apparent associations between hallucinogen use and psychosis appear largely attributable to baseline psychiatric comorbidities rather than direct causal effects.
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PCC
Prevalence of Anxiety in an Underserved Population
Original Research

June 9, 2026

Generalized anxiety disorder is highly prevalent in underserved Venezuelan populations, particularly among women, highlighting the need for routine screening in primary care settings
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PCC
ECT for Psychosis in Huntington Disease-Like 2
Case Report

May 19, 2026

A 47-year-old woman with genetically confirmed Huntington disease-like 2 had refractory psychosis and functional decline but responded well to electroconvulsive therapy.
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PCC
Adjunct Memantine for Inappropriate Sexual Behavior
Case Report

May 14, 2026

Two patients with intellectual disability and major neurocognitive disorder exhibited inappropriate sexual behavior that significantly decreased after memantine was added as adjunctive therapy.
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PCC
From Physical to Digital: Hoarding Phenomena in Obsessive-Compulsive Disorder
Case Report

May 14, 2026

This case illustrates how hoarding phenomenology can manifest in digital environments, which offer virtually unlimited storage, anonymity, and low visibility.
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PCC
Aripiprazole-Induced Pathological Gambling
Case Report

May 7, 2026

A 27-year-old man with a history of substance abuse developed a new-onset compulsive gambling pattern within weeks of starting aripiprazole.
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PCC
Clozapine-Associated Pulmonary Embolism
Case Report

May 5, 2026

A 48-year-old woman with schizoaffective disorder taking clozapine developed acute pulmonary embolism despite negative D-dimer results.
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PCC
Polydipsia-Related Hyponatremia in Autism
Case Report

April 30, 2026

The authors present the case of a 10-year-old boy with autism who presented to the ED with hyponatremia-related seizures due to compulsive water drinking.
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