The Journal of
Clinical Psychiatry

Volume 78 • 2017 • 9

Publisher's Note

Thirty Great Years

J Clin Psychiatry 2017;78(9):1329

John S. Shelton, PhD

Editorial

All Good Things

J Clin Psychiatry 2017;78(9):1330

Alan J. Gelenberg, MD

Meta-Analysis

Review and Meta-Analysis of Epidemiologic Studies of Adult Bipolar Disorder

J Clin Psychiatry 2017;78(9):e1259-e1269

Eric A. Youngstrom, PhD; Ana Lúcia R. Moreira, MD; Anna Van Meter, PhD; Jacquelynne Genzlinger, BA

Original Research

Relationship Between Current Depressive Symptoms and Telomere Length in a Large, Multiethnic Sample

J Clin Psychiatry 2017;78(9):1331-1336

E. Sherwood Brown, MD, PhD; Nicholas D. Wignall, PhD; Martin Deschner, PhD; Harry M. Evans, PhD

Original Research

Genetic Risk Score Analysis in Early-Onset Bipolar Disorder

J Clin Psychiatry 2017;78(9):1337-1343

Karen Dineen Wagner, MD, PhD; Mark A. Frye, MD; Paul E. Croarkin, DO, MSCS; Susan L. McElroy, MD; John T. Walkup, MD; Joanna M. Biernacka, PhD; Joan L. Luby, MD; Kelly Cercy, BS; Jennifer R. Geske, MS; Marin Veldic, MD; Matthew Simonson, PhD; Paramjit T. Joshi, MD; Malik M. Nassan, MBBS; Alfredo B. Cuellar-Barboza, MD; Leah Casuto, MD; Peter S. Jensen, MD

Original Research

The Effects of Valbenazine in Participants with Tardive Dyskinesia: Results of the 1-Year KINECT 3 Extension Study

J Clin Psychiatry 2017;78(9):1344-1350

Gary Remington, MD, PhD; Christoph U. Correll, MD; Stewart A. Factor, DO; Cynthia L. Comella, MD; Joshua Burke, MS; Roland Jimenez, BA; Grace S. Liang, MD; Christopher F. O' Brien, MD

Original Research

Treating Prolonged Grief Disorder: A 2-Year Follow-Up of a Randomized Controlled Trial

J Clin Psychiatry 2017;78(9):1363-1368

Richard A. Bryant, PhD; Angela Nickerson, PhD; Lucy Kenny, PhD; Amy Joscelyne, PhD; Natasha Rawson, MPsychol; Fiona Maccallum, PhD; Catherine Cahill, MPsychol; Sally Hopwood, MPsychol

Original Research

Telephone-Based Depression Care Management for Postpartum Women: A Randomized Controlled Trial

J Clin Psychiatry 2017;78(9):1369-1375

Stephen R. Wisniewski, PhD; Katherine L. Wisner, MD, MS; James F. Luther, MA; Heather F. Eng, BA; John L. Dills, MLIS; Dorothy K. Y. Sit, MD; Mary McShea, MA; Eydie L. Moses-Kolko, MD

Original Research

Development of a Computerized Adaptive Test Suicide Scale—The CAT-SS

J Clin Psychiatry 2017;78(9):1376-1382

Ellen Frank, PhD; Robert D. Gibbons, PhD; Tara Moore, MA, MPH; David Kupfer, MD; David G. Beiser, MD, MS; Edwin D. Boudreaux, PhD

Original Research

Advanced Glycation End Products in Recent-Onset Psychosis Indicate Early Onset of Cardiovascular Risk

J Clin Psychiatry 2017;78(9):1395-1401

Julia M. Hagen, MD; Arjen L. Sutterland, MD; Maarten W. Koeter, PhD; Rene Lutter, PhD; Dan Cohen, MD, PhD; Lieuwe de Haan, MD, Prof

Original Research

Risk of Suicide Attempts Among Adolescents and Young Adults With Autism Spectrum Disorder: A Nationwide Longitudinal Follow-Up Study

J Clin Psychiatry 2017;78(9): e1174-e1179

Tung-Ping Su, MD; Mu-Hong Chen, MD; Tai-Long Pan, PhD; Ju-Wei Hsu, MD; Kai-Lin Huang, MD; Cheng-Ta Li, MD, PhD; Wei-Chen Lin, MD; Tzeng-Ji Chen, MD, PhD; Ya-Mei Bai, MD, PhD; Wen-Hsuan Lan, MD; Han-Ting Wei, MD

Original Research

The Implication of Combat Stress and PTSD Trajectories in Metabolic Syndrome and Elevated C-Reactive Protein Levels: A Longitudinal Study

J Clin Psychiatry 2017;78(9):e1180-e1186

Zahava Solomon, PhD; Yafit Levin; Einor Ben Assayag, PhD; Orit Furman, PhD; Shani Shenhar-Tsarfaty, PhD; Shlomo Berliner, MD; Avi Ohry, MD

Original Research

Anosognosia Is an Independent Predictor of Conversion From Mild Cognitive Impairment to Alzheimer's Disease and Is Associated With Reduced Brain Metabolism

J Clin Psychiatry 2017;78(9):e1187-e1196

Original Research

The Diagnostic Challenge of the Late-Onset Frontal Lobe Syndrome: Clinical Predictors for Primary Psychiatric Disorders Versus Behavioral Variant Frontotemporal Dementia

J Clin Psychiatry 2017;78(9):e1197-e1203

Philip Scheltens, MD, PhD; Everard G. B. Vijverberg, MD, PhD; Flora Gossink, MD; Welmoed Krudop, MD, PhD; Sietske Sikkes, MSc, PhD; Cora Kerssens, MD; Niels Prins, MD, PhD; Max Stek, MD, PhD; Yolande Pijnenburg, MD, PhD; Annemiek Dols, MD, PhD

Original Research

Placebo Effects in the Treatment of Noncognitive Symptoms of Alzheimer's Disease: Analysis of the CATIE-AD Data

J Clin Psychiatry 2017;78(9):e1204-e1210

Suzanne Reeves, PhD; Hiroyuki Uchida, MD, PhD; Robert Howard, MD; Takayuki Abe, PhD; Masaru Mimura, MD, PhD; Takefumi Suzuki, MD, PhD; Barry Lebowitz, PhD; Kazunari Yoshida, MD; Chisa Ozawa, MD; Rachel Roberts, MS

Original Research

Dried Blood Spot Analysis for Therapeutic Drug Monitoring of Clozapine

J Clin Psychiatry 2017;78(9):e1211-e1218

Dan Cohen, MD, PhD; Lisanne M. Geers, PharmD; Laura M. Wehkamp, PharmD; Kai van Hateren, MSc; Remco A. Koster, PhD; Olga Yu Fedorenko, MD, PhD; Arkadyi V. Semke, MD, PhD; Nikolay Bokhan, MD, PhD; Svetlana A. Ivanova, MD, PhD; Jos G. W. Kosterink, PharmD, PhD; Anton J. M. Loonen, PharmD, MD, PhD; Daan J. Touw, PharmD, PhD

Original Research

Elevated Proinflammatory Markers in 22q11.2 Deletion Syndrome Are Associated With Psychosis and Cognitive Deficits

J Clin Psychiatry 2017;78(9):e1219-e1225

Abraham Weizman, MD; Ehud Mekori-Domachevsky, MD; Michal Taler, PhD; Yehuda Shoenfeld, MD; Michael Gurevich, PhD; Polina Sonis, MSc; Omri Weisman, PhD; Doron Gothelf, MD

Original Research

Seizure Risk Associated With Antidepressant Treatment Among Patients With Depressive Disorders: A Population-Based Case-Crossover Study

J Clin Psychiatry 2017;78(9):e1226-e1232

Chi-Shin Wu, MD, PhD; Hui-Ju Tsai, MPH, PhD; Shi-Kai Liu, MD; Hsin-Yen Liu, BS

Original Research

The Association Between Comorbid Autism Spectrum Disorders and Antipsychotic Treatment Failure in Early-Onset Psychosis: A Historical Cohort Study Using Electronic Health Records

J Clin Psychiatry 2017;78(9):e1233-e1241

Matthew Hotopf, PhD, MRCPsych; Johnny M. Downs, MSc, MRCPsych; Suzannah Lechler, MSc; Harry Dean, MSc; Nicola Sears, MSc; Rashmi Patel, PhD, MRCPsych; Hitesh Shetty, MSc; Emily Simonoff, MD, FRCPsych; Tamsin J. Ford, PhD, FRCPsych; Covadonga M. Diaz-Caneja, MD; Celso Arango, MD, PhD; James H. MacCabe, PhD, FRCPsych; Richard D. Hayes, PhD; Laura Pina-Camacho, MD, PhD

Original Research

Treatment to Enhance Cognition in Bipolar Disorder (TREC-BD): Efficacy of a Randomized Controlled Trial of Cognitive Remediation Versus Active Control

J Clin Psychiatry 2017;78(9):e1242-e1249

Kathryn E. Lewandowski, PhD; Sarah H. Sperry, MA; Bruce M. Cohen, MD, PhD; Lesley A. Norris, BA; Garrett M. Fitzmaurice, PhD; Dost Ongur, MD, PhD; Matcheri S. Keshavan, MD

Original Research

National Trends in and Correlates of Nonmedical Use of Prescription Stimulants, Nonmedical Use Frequency, and Use Disorders

J Clin Psychiatry 2017;78(9):e1250-e1258

Carlos Blanco, MD, PhD; Wilson M. Compton, MD, MPE; Beth Han, MD, PhD, MPH; Christopher M. Jones, PharmD, MPH

Original Research

Reducing Anticholinergic Medication Burden in Patients With Psychotic or Bipolar Disorders

J Clin Psychiatry 2017;78(9):e1270-e1275

K. N. Roy Chengappa, MD, FRCPC; Kimberly Clinebell, MD; Ana M. Lupu, PharmD; Jessica M. Gannon, MD; Justin C. Ellison, PharmD, BCPP

Original Research

Prescribing Patterns in a Psychiatrically Referred Sample of Youth With Autism Spectrum Disorder

J Clin Psychiatry 2017;78(9):e1276-e1283

Joseph Biederman, MD; Janet Wozniak, MD; Maura Fitzgerald, MPH; Gagan Joshi, MD; Julia Shekunov, MD; Kristina Conroy, BA; Elizabeth Pinsky, MD; Melissa F. de Leon; Abigail Belser, BA

Original Research

Anticholinergic Burden and Cognition in Older Patients With Schizophrenia

J Clin Psychiatry 2017;78(9):e1284-e1290

Benoit H. Mulsant, MD, MS; Bruce G. Pollock, MD, PhD; Christopher Tsoutsoulas, BSc (Hons); Sanjeev Kumar, MD; Zaid Ghazala, MBBS; Aristotle N. Voineskos, MD, PhD; Mahesh Menon, PhD; Tarek K. Rajji, MD

Original Research

Clinical and Genetic Predictors of Delayed Remission After Multiple Levels of Antidepressant Treatment: Toward Early Identification of Depressed Individuals for Advanced Care Options

J Clin Psychiatry 2017;78(9):e1291-e1298

Richard C. Shelton, MD; Michael I. Falola, MD, MPH; Nita Limdi, PharmD, PhD, MSPH, FAHA

Original Research

Naltrexone and Disulfiram Treatment Response in Veterans With Alcohol Dependence and Co-Occurring Problem-Gambling Features

J Clin Psychiatry 2017;78(9):e1299-e1306

Ismene L. Petrakis, MD; Jon E. Grant, JD, MD; Marc N. Potenza, MD, PhD; Shane W. Kraus, PhD

Article

Findings of Interest

J Clin Psychiatry 2017;78(9):1402-1403

Karen Dineen Wagner, MD, PhD

Article

Cannabis Use and Cannabis Use Disorders Among Youth in the United States, 2002-2014

J Clin Psychiatry 2017;78(9):1404-1413

Carlos Blanco, MD, PhD; Wilson M. Compton, MD, MPE; Beth Han, MD, PhD, MPH; Christopher M. Jones, PharmD, MPH

Article

Persistent Negative Symptoms in First-Episode Psychosis: Early Cognitive and Social Functioning Correlates and Differences Between Early and Adult Onset

J Clin Psychiatry 2017;78(9):1414-1422

Eduard Vieta, PhD; Ana Gonzalez-Pinto, PhD; Judith Usall, PhD; Iluminada Corripio, PhD; Julio Bobes, PhD; Josefina Castro-Fornieles, PhD; Mara Parellada, PhD; Olga Puig, PhD; Immaculada Baeza, PhD; Elena de la Serna, PhD; Bibiana Cabrera, MsC; Gisela Mezquida, MsC; Miquel Bioque, PhD; Antonio Lobo, PhD; Fernando Contreras, PhD; Manuel J. Cuesta, PhD; Miquel Bernardo, PhD; PEPs Group

Article

A Supervised Exercise Intervention for Youth at Risk for Psychosis: An Open-Label Pilot Study

J Clin Psychiatry 2017;78(9):e1167-e1173

Derek J. Dean, MA; Angela D. Bryan, PhD; Raeana Newberry, BA; Tina Gupta, BA; Emily Carol, MA; Vijay A. Mittal, PhD

Article

Baseline Characteristics and Early Response at Week 1 Predict Treatment Outcome in Adolescents With Bipolar Manic or Mixed Episode Treated With Olanzapine: Results From a 3-Week, Randomized, Placebo-Controlled Trial

J Clin Psychiatry 2017;78(9):e1158-e1166

Stephen J. Ganocy, PhD; Robert L. Findling, MD, MBA; Kiki Chang, MD; Mauricio Tohen, MD, DrPH, MBA; John M. Kane, MD; Christoph U. Correll, MD; Melissa P. DelBello, MD, MS; Yu-Tao Xiang, MD, PhD; Le Xiao, MD

Academic Highlights

Cognitive Impairment in Patients With Depression: Awareness, Assessment, and Management

J Clin Psychiatry 2017;78(9):1383-1394

Larry Culpepper, MD, MPH; Raymond W. Lam, MD, FRCPC; Roger S. McIntyre, MD, FRCPC

Academic Highlights

Utilizing the DSM-5 Anxious Distress Specifier to Develop Treatment Strategies for Patients With Major Depressive Disorder

J Clin Psychiatry 2017;78(9):1351-1362

Madhukar H. Trivedi, MD; Michael E. Thase, MD; J. Sloan Manning, MD; Richard H. Weisler, MD

Commentary

Is Psychiatric Epidemiology Still Counting?

J Clin Psychiatry 2017;78(9):e1314-e1315

Myrna M. Weissman, PhD

Commentary

The Few Who Served Deserved to Be Cared For

J Clin Psychiatry 2017;78(9):e1313

John H. Shale, MD, JD

Clinical and Practical Psychopharmacology

Memantine as an Augmentation Treatment for Schizophrenia: Limitations of Meta-Analysis for Evidence-Based Evaluation of Research

J Clin Psychiatry 2017;78(9):e1307-e1309

Chittaranjan Andrade, MD

Clinical and Practical Psychopharmacology

Patient Education in Psychopharmacology and the Risk of Nocebo-Related Treatment Inefficacy and Harm

J Clin Psychiatry 2017;78(9):e1310-e1312

Chittaranjan Andrade, MD

ASCP Corner

Management of New Onset Psychosis in the Postpartum Period

J Clin Psychiatry 2017;78(9):1423-1424

Kristina M. Deligiannidis, MD; Amanda Tinkelman, MD; Emily A. Hill, MD

Letter to the Editor

The Gap Between the Randomized Controlled Trial-Based Evidence and Real-World Practice in Switching Strategies of Major Depressive Disorder

J Clin Psychiatry 2017;78(9):e1316

Kui Chen, MD; Qiyi Mei, BM

Letter to the Editor

Drs Bschor and Baethge Reply

J Clin Psychiatry 2017;78(9):e1317

Tom Bschor, MD; Christopher Baethge, MD

Letter to the Editor

Antidepressant Response and Dissociative Effects After Ketamine Treatment: Two Sides of the Same Coin?

J Clin Psychiatry 2017;78(9):e1318

Francesco Bartoli, PhD; Massimo Clerici, PhD; Giuseppe CarrÃ , PhD

Letter to the Editor

Dr Andrade Replies to Antidepressant Response and Dissociative Effects After Ketamine Treatment

J Clin Psychiatry 2017;78(9):e1319

Chittaranjan Andrade, MD

Letter to the Editor

Cognitive Planning Neural Correlates in a Pediatric Monozygotic Twin Pair Discordant for Obsessive-Compulsive Disorder: Exploring Potential Application in Precision Medicine

J Clin Psychiatry 2017;78(9):e1320-e1321

Fern Jaspers-Fayer, PhD; Juliana Negreiros, PhD; Sarah Yao Lin, MSc; aura Belschner, MSc; S. Evelyn Stewart, MD

Educational Activity

Epidemiology and Prevention of Tardive Dyskinesia

J Clin Psychiatry 2017;78(9):e1426

Christoph U. Correll, MD

Educational Activity

Available Tools for Assessing Cognitive Impairment in Major Depressive Disorder

J Clin Psychiatry 2017;78(9):e1427

Roger S. McIntyre, MD, FRCPC

Educational Activity

Assessing Patients for Tardive Dyskinesia

J Clin Psychiatry 2017;78(9):e1428

John M. Kane, MD

Educational Activity

Comparing Treatments for Tardive Dyskinesia

J Clin Psychiatry 2017;78(9):e1429

Leslie L. Citrome, MD, MPH

Educational Activity

Impact of Cognitive Impairment on Functioning in Patients With Depression

J Clin Psychiatry 2017;78(9):e1430

Raymond W. Lam, MD, FRCPC

Educational Activity

Improving Long-Term Outcomes in Patients With Schizophrenia: What Is the Evidence for Long-Acting Injectable Antipsychotics?

J Clin Psychiatry 2017;78(9):e1431

Diana O. Perkins, MD, MPH

Educational Activity

Strategies for Managing Patients With Depression Who Are Experiencing Cognitive Impairment

J Clin Psychiatry 2017;78(9):e1432

Larry Culpepper, MD, MPH

Volume 78 • 2017 • 9

Publisher's Note

Thirty Great Years

Editorial

All Good Things

Meta-Analysis

Review and Meta-Analysis of Epidemiologic Studies of Adult Bipolar Disorder

Original Research

Relationship Between Current Depressive Symptoms and Telomere Length in a Large, Multiethnic Sample

Genetic Risk Score Analysis in Early-Onset Bipolar Disorder

The Effects of Valbenazine in Participants with Tardive Dyskinesia: Results of the 1-Year KINECT 3 Extension Study

Treating Prolonged Grief Disorder: A 2-Year Follow-Up of a Randomized Controlled Trial

Telephone-Based Depression Care Management for Postpartum Women: A Randomized Controlled Trial

Development of a Computerized Adaptive Test Suicide Scale—The CAT-SS

Advanced Glycation End Products in Recent-Onset Psychosis Indicate Early Onset of Cardiovascular Risk

Risk of Suicide Attempts Among Adolescents and Young Adults With Autism Spectrum Disorder: A Nationwide Longitudinal Follow-Up Study

The Implication of Combat Stress and PTSD Trajectories in Metabolic Syndrome and Elevated C-Reactive Protein Levels: A Longitudinal Study

Anosognosia Is an Independent Predictor of Conversion From Mild Cognitive Impairment to Alzheimer's Disease and Is Associated With Reduced Brain Metabolism

The Diagnostic Challenge of the Late-Onset Frontal Lobe Syndrome: Clinical Predictors for Primary Psychiatric Disorders Versus Behavioral Variant Frontotemporal Dementia

Placebo Effects in the Treatment of Noncognitive Symptoms of Alzheimer's Disease: Analysis of the CATIE-AD Data

Dried Blood Spot Analysis for Therapeutic Drug Monitoring of Clozapine

Elevated Proinflammatory Markers in 22q11.2 Deletion Syndrome Are Associated With Psychosis and Cognitive Deficits

Seizure Risk Associated With Antidepressant Treatment Among Patients With Depressive Disorders: A Population-Based Case-Crossover Study

The Association Between Comorbid Autism Spectrum Disorders and Antipsychotic Treatment Failure in Early-Onset Psychosis: A Historical Cohort Study Using Electronic Health Records

Treatment to Enhance Cognition in Bipolar Disorder (TREC-BD): Efficacy of a Randomized Controlled Trial of Cognitive Remediation Versus Active Control

National Trends in and Correlates of Nonmedical Use of Prescription Stimulants, Nonmedical Use Frequency, and Use Disorders

Reducing Anticholinergic Medication Burden in Patients With Psychotic or Bipolar Disorders

Prescribing Patterns in a Psychiatrically Referred Sample of Youth With Autism Spectrum Disorder

Anticholinergic Burden and Cognition in Older Patients With Schizophrenia

Clinical and Genetic Predictors of Delayed Remission After Multiple Levels of Antidepressant Treatment: Toward Early Identification of Depressed Individuals for Advanced Care Options

Naltrexone and Disulfiram Treatment Response in Veterans With Alcohol Dependence and Co-Occurring Problem-Gambling Features

Article

Findings of Interest

Cannabis Use and Cannabis Use Disorders Among Youth in the United States, 2002-2014

Persistent Negative Symptoms in First-Episode Psychosis: Early Cognitive and Social Functioning Correlates and Differences Between Early and Adult Onset

A Supervised Exercise Intervention for Youth at Risk for Psychosis: An Open-Label Pilot Study

Baseline Characteristics and Early Response at Week 1 Predict Treatment Outcome in Adolescents With Bipolar Manic or Mixed Episode Treated With Olanzapine: Results From a 3-Week, Randomized, Placebo-Controlled Trial

Academic Highlights

Cognitive Impairment in Patients With Depression: Awareness, Assessment, and Management

Utilizing the DSM-5 Anxious Distress Specifier to Develop Treatment Strategies for Patients With Major Depressive Disorder

Commentary

Is Psychiatric Epidemiology Still Counting?

The Few Who Served Deserved to Be Cared For

Clinical and Practical Psychopharmacology

Memantine as an Augmentation Treatment for Schizophrenia: Limitations of Meta-Analysis for Evidence-Based Evaluation of Research

Patient Education in Psychopharmacology and the Risk of Nocebo-Related Treatment Inefficacy and Harm

ASCP Corner

Management of New Onset Psychosis in the Postpartum Period

Letter to the Editor

The Gap Between the Randomized Controlled Trial-Based Evidence and Real-World Practice in Switching Strategies of Major Depressive Disorder

Drs Bschor and Baethge Reply

Antidepressant Response and Dissociative Effects After Ketamine Treatment: Two Sides of the Same Coin?

Dr Andrade Replies to Antidepressant Response and Dissociative Effects After Ketamine Treatment

Cognitive Planning Neural Correlates in a Pediatric Monozygotic Twin Pair Discordant for Obsessive-Compulsive Disorder: Exploring Potential Application in Precision Medicine

Educational Activity

Epidemiology and Prevention of Tardive Dyskinesia

Available Tools for Assessing Cognitive Impairment in Major Depressive Disorder

Assessing Patients for Tardive Dyskinesia

Comparing Treatments for Tardive Dyskinesia

Impact of Cognitive Impairment on Functioning in Patients With Depression

Improving Long-Term Outcomes in Patients With Schizophrenia: What Is the Evidence for Long-Acting Injectable Antipsychotics?

Strategies for Managing Patients With Depression Who Are Experiencing Cognitive Impairment

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