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Case Report

Adjunctive Oxycodone for the Treatment of Refractory Bipolar Depression

Jason E. Schiffman, MD, and Michael J. Gitlin, MD

Published: July 15, 2012

Article Abstract

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There have been several case reports and open trials reporting the efficacy of opioids as treatment for depression. These have included the µ-opioid receptor full agonists oxycodone, oxymorphone, and human β-endorphin peptide as well as the µ-opioid receptor partial agonist buprenorphine. Despite this reported efficacy, these agents are generally considered to be treatments of last resort in psychiatric disorders given the risk of iatrogenic opioid dependence, to which this patient population may be particularly susceptible.

Volume: 73

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