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Case Report

Cytochrome P450 2D6 Polymorphism and Its Impact on Decision-Making in Psychopharmacotherapy: Finding the Right Way in an Ultrarapid Metabolizing Patient

Michael Paulzen, MD; Simone C. Tauber, MD; André Kirner-Veselinovic, MD; and Gerhard Gründer, MD

Published: November 15, 2011

Article Abstract

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The cytochrome P450 (CYP) superfamily represents the most important phase I drug metabolizing enzyme system. Genetic mutations play an important role in the activity especially of CYP2D6. Genetic polymorphisms within CYPs affect the metabolism of drugs as substrates for the particular enzymes, resulting in variations in plasma levels of the drugs, differences in drug response, or altered risk for adverse effects.

Volume: 72

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