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Letter to the Editor

Dr. Lindenmayer Replies

Jean-Pierre Lindenmayer, MD

Published: January 15, 2008

Article Abstract

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Sir: In his letter to the editor, Dr. Murphy opines against theuse of a first-generation antipsychotic as a comparator in ourstudy,1 stating that "the mean dose of haloperidol used (17.11mg) invariably induces secondary negative symptoms."However, there is little evidence that haloperidol systematicallyinduces secondary negative symptoms. In fact, 2recent studies2,3 comparing the effects of olanzapine, a secondgenerationantipsychotic with a very benign extrapyramidalsymptom profile, with haloperidol at doses similar to those usedin our study combined with benztropine found no significantdifferences for positive or negative symptoms in schizophreniabetween the 2 antipsychotics. ‘ ‹

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Volume: 69

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