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Letter to the Editor

Drs. Meltzer and Jayathilake Reply

Herbert Y. Meltzer, MD, and Karu Jayathilake, PhD

Published: October 31, 2008

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Sir: Dr. Jeffrey Mattes’s criticism of the power analysis inour study is, in part, well taken, if we did not make it sufficientlyclear that dropouts were considered in our originalpower analysis.

We had calculated that it was necessary to recruit 40 subjectsper treatment arm in order to achieve 80% power with an expected25% dropout rate. However, we were unable to recruitmore than 21 and 19 patients in the clozapine and olanzapinearms, respectively.’ ‹

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