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Letter to the Editor

Drs. Sysko and Walsh Reply

Robyn Sysko, PhD, and B. Timothy Walsh, MD

Published: August 27, 2008

Article Abstract

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Sir: We appreciate the points made by Drs. Vieta and Cruz intheir comment on our recent review of controlled trials of bipolarmania.1 Our review noted a relative paucity of data availablefor analysis and important differences across study designsin the trials included in the analysis, limiting our confidence inthe indications that placebo response rates had changed overtime.1 We therefore restricted our discussion of factors thatmight have contributed to an increase in response rates, as itwas not clear whether such changes had, in fact, occurred.’ ‹

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Volume: 69

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