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Letter to the Editor

Injection Site Pain With Long-Acting Risperidone

Narsimha R. Pinninti, BS; and Rajnish Mago, MD

Published: May 15, 2005

Article Abstract

Because this piece has no abstract, we have provided for your benefit the first 3 sentences of the full text.’ ‹

Sir: In a recent report in the Journal,1 only 1 of 141 patientsin a 12-week multicenter trial of injectable long-acting risperidonecomplained of pain at the site of injection, which was mild.Pain at the injection site has been noted to be a problem withfirst-generation antipsychotics.2,3 The authors speculated thatthe water-based formulation of risperidone might account forthe low frequency of injection site pain. In a previous study,4patient ratings of pain on a visual analogue scale after injectionsof long-acting risperidone were similar to ratings of pain afterinjections of placebo after the first and sixth injections.’ ‹

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Volume: 66

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