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Letter to the Editor

Metrifonate for Alzheimer’s Disease Patients

Lon S. Schneider

Published: August 31, 2000

Article Abstract

Letter to the Editor

Sir: Metrifonate, an organophosphate compound synthesizedin the 1950s, is widely used as an insecticide for fruit andfield crops, as an antiparasitic agent for domestic animals, andas a second-line antischistosomiasis agent in humans. Becauseof the irreversible cholinesterase inhibitor propertiesof metrifonate, Becker and colleagues proposed it for improvingcognitive function in patients with Alzheimer’s disease.Published and unpublished results of phase 3 clinical trials generallysupport metrifonate’s essential cognitive efficacy.

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