This work may not be copied, distributed, displayed, published, reproduced, transmitted, modified, posted, sold, licensed, or used for commercial purposes. By downloading this file, you are agreeing to the publisher’s Terms & Conditions.


Neurochemistry in the Pathophysiology of Autism.

Christopher J. McDougle, MD; Craig A. Erickson, MD; Kimberly A. Stigler, MD; and David J. Posey, MD

Published: December 15, 2005

Article Abstract

Significant progress has been made in the search for underlying pathophysiologic mechanismsin autism over the past 50 years. The cause of the disorder, however, remains largely unknown. Thisarticle reviews neurochemical contributions to the pathophysiology of autism with a focus on monoamines,glutamate/γ-aminobutyric acid systems, and neuropeptides. As these efforts move forward, itwill be important to begin to integrate genetic studies with those involving neuroimaging and post-mortemresearch in each of these 3 areas, as well as with pharmacologic treatment approaches

Some JCP and PCC articles are available in PDF format only. Please click the PDF link at the top of this page to access the full text.

Related Articles

Volume: 66

Quick Links: