The Journal of Clinical Psychiatry The Journal of Clinical Psychiatry

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Clinical Psychiatry

Empowering mental health professionals with peer-reviewed psychiatric research and insights

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JCP
The Near-Term Future of Muscarinic Agonists and Modulators for Schizophrenia: M1 and/or M4
Insights

February 21, 2025

In this video, Dr. Kantrowitz explores the potential of muscarinic acetylcholine receptor (mACHR) agonists and modulators for schizophrenia treatment, with a focus on M1 and M4 receptors. He reviews…
JCP
Brexpiprazole in Combination with Sertraline and as Monotherapy in PTSD: A Full-Factorial Randomized Clinical Trial
Original Research

February 19, 2025

In this 10-week study, brexpiprazole in combination with sertraline, but not as monotherapy, demonstrated the potential to be a new efficacious treatment for PTSD.
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JCP
Sequencing Stimulants and Behavioral Parent Training in Multiplex ADHD Families
Original Research

February 19, 2025

Combination treatment may be helpful for most multiplex ADHD families, and sequencing treatments with behavioral parent training first followed by stimulant medication for the mother may be the most…
, , , et al
JCP
Semaglutide-Induced Euphoria in a Patient With Bipolar Disorder
Case Report

February 17, 2025

A 77-year-old woman with bipolar disorder experienced transient euphoria following semaglutide use for obesity.
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JCP
Long-Term Safety and Efficacy of Esmethadone in MDD
Original Research

February 17, 2025

A durable improvement in MDD symptoms for up to 1 year was observed with esmethadone with high rates of response and remission.
, , , et al
JCP
Target Trial Emulation: A Concept Simply Explained
Clinical and Practical Psychopharmacology

February 12, 2025

Target trial emulation can address study objectives that, for ethical or logistic reasons, cannot easily be examined in RCTs. Read this article to learn about the methodology and explore…
JCP
Correction

February 11, 2025

JCP
Psychological Support in Psychedelic Therapy
Original Research

February 5, 2025

The survey reveals differences of opinion among psychedelic researchers, with a slight trend toward preference for an emotive approach to psychological support.
, , , et al
JCP
Suicidal Behaviors and Obstructive Sleep Apnea
Original Research

February 3, 2025

Based on findings from the STOP-Bang questionnaire, suicidal behaviors may be more common in patients with obstructive sleep apnea (OSA) than in those without OSA.
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JCP
Racial Disparities in Mood Stabilizer Prescribing in Mania
Original Research

February 3, 2025

Significant disparities in prescription rates of valproic acid and lithium were observed, with Black patients more likely to receive valproic acid and less likely to receive lithium compared to…
, , , et al
JCP
Relationship Between Trauma, PTSD, and Schizophrenia
ASCP Corner

January 29, 2025

The authors summarize the clinical relevance of trauma and PTSD in patients with schizophrenia and examine assessment and treatment options of trauma and related conditions to consider when treating…
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JCP
ECT for Psychotic vs Nonpsychotic Depression
Original Research

January 29, 2025

Patients with major depression with psychotic features had higher response rates to ECT than those without psychotic features and similar rates of adverse cognitive effects. After adjustment for confounders,…
, , , et al

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