The Journal of Clinical Psychiatry The Journal of Clinical Psychiatry

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Clinical Psychiatry

Empowering mental health professionals with peer-reviewed psychiatric research and insights

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JCP
Esketamine Nasal Spray vs Quetiapine ER in Treatment-Resistant Depression
Original Research

January 27, 2025

Esketamine was associated with significantly larger improvements in work productivity loss and related costs compared to quetiapine, suggesting greater benefits from patient well-being and employer perspectives.
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JCP
Psychological Challenges of Adults with SMI during the COVID-19 Pandemic
Original Research

January 22, 2025

Adults with SMI diagnosed with COVID-19 and those who sheltered in place during lockdown experienced more severe psychological distress compared to those not diagnosed with COVID-19.
, , , et al
JCP
Suicides by Sodium Nitrite Reported to US Poison Centers
Brief Report

January 22, 2025

During 2020-2023, the number of sodium nitrate exposure cases peaked at 39 in 2022, with a drop to 29 in 2023. Case fatality was 41.5%.
,
JCP
Sulforaphane Added to Antipsychotics for Negative Symptoms of Schizophrenia
Original Research

January 20, 2025

Add-on high dose sulforaphane may reduce negative symptoms in patients with schizophrenia, although the clinical significance of this reduction needs further evaluation.
, , , et al
JCP
Synopsis of the VA/DOD Clinical Practice Guideline for Management of Bipolar Disorder
Consensus Statement

January 13, 2025

This synopsis focuses on clinically relevant recommendations related to identification and management of bipolar disorder, including the acute and maintenance phases of illness.
, , , et al
JCP
BI 1358894 in Borderline Personality Disorder
Original Research

January 13, 2025

Although the primary endpoint was not met, BI 1358894 was well-tolerated with no increase in self-harm or suicidality.
, , , et al
JCP
Inpatient Treatment of Suicidality
Systematic Review

January 8, 2025

Effective, rapid treatments that target suicidality in psychiatric inpatients are scarce in the existing literature and in clinical practice, underscoring the need for studies to identify and validate these…
, , , et al
JCP
Cardiovascular Risk Factors and Second Generation Antipsychotics
Original Research

January 8, 2025

Despite well-documented cardiovascular disease (CVD) morbidity and mortality, CVD risks among people with severe mental illness who use antipsychotics are common and frequently untreated.
, , , et al
JCP
Cannabis Use During Pregnancy and Neuropsychiatric Adverse Outcomes in Children and Young Adults
Clinical and Practical Psychopharmacology

January 6, 2025

Current research suggests that prenatal cannabis exposure is linked to many adverse outcomes, including psychosis proneness, psychotic-like experiences, internalizing and externalizing problems, attention problems, thought-related problems, social problems, impaired…
JCP
IV Hydroxyzine vs Haloperidol for Delirium
Original Research

January 6, 2025

Hydroxyzine showed a significantly higher rate of delirium improvement than haloperidol, with no significant difference in the time to improvement.
, , , et al
JCP
Olanzapine/Samidorphan Effects on Weight Gain
Original Research

January 2, 2025

Treatment with a combination of olanzapine and samidorphan was associated with less weight gain and reduced risk of reaching ≥7% or ≥10% gain in body weight versus olanzapine over…
, , , et al
JCP
Substance and Opioid Use Disorders Among IBD Hospitalizations
Original Research

January 2, 2025

A higher prevalence of SUD and opioid use disorder was found among hospitalizations for inflammatory bowel disease, and these elevated prevalences were linked to distinct demographic, socioeconomic, and geographic…
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