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Letter to the Editor

Vagus Nerve Stimulation Improves Restless Legs Syndrome Associated With Major Depression: A Case Report

Angela Merkl, MD; Eva Lotta Brakemeier, MSc; Heidi Danker-Hopfe, MD, PhD; and Malek Bajbouj, MD

Published: April 16, 2007

Article Abstract

Because this piece does not have an abstract, we have provided for your benefit the first 3 sentences of the full text.

Sir: Vagus nerve stimulation (VNS) has shown effects in treatment-resistant epilepsy1 and major depressive episode.2 Epidemiologic studies have described restless legs syndrome (RLS) to exist in varying degrees of severity in 2.5% to 10% of the population.3 Treatment of first choice is dopamine agonists, but agents that enhance inhibitory mechanisms in the way that anticonvulsive drugs do are effective, too.’ ‹

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