Original Research

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Recently published articles about Original Research

JCP
Efficacy of Olanzapine/Samidorphan on Negative Symptoms
Original Research

March 9, 2026

Olanzapine/samidorphan was associated with significant and durable improvement in negative symptoms of schizophrenia, overall and among patients with prominent and predominant negative symptoms.
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JCP
Comparing Risk Prediction for Suicide Attempts and Deaths After Emergency Department Visits
Original Research

March 4, 2026

Distinct factors predict nonfatal and fatal suicidal events. Male sex and depression are the strongest predictors for fatal events; being under 65 years of age and suicidal ideation are...
, , , et al
PCC
Depression and Cardiovascular Disease in Aging Populations
Original Research

March 3, 2026

Even infrequent depressive symptoms are associated with elevated CVD risk in older adults, and those with both depressive symptoms and obesity or smoking have higher odds.
, , , et al
JCP
Outcomes and Practice Patterns of LAI Versus Oral Antipsychotics Among Patients With Bipolar I Disorder in the US
Original Research

March 2, 2026

Long-acting injectable antipsychotics, especially second-generation formulations, are associated with reduced rehospitalization in bipolar I disorder compared to oral antipsychotics.
, , , et al
PCC
Validation of the APREMDI Scale for Brazilian Portuguese
Original Research

February 19, 2026

The APREMDI scale allows clinicians to quantitatively assess patients’ perceptions of respect and dignity during hospitalization, helping to identify subtle dignity violations that may compromise recovery and satisfaction.
, , , et al
JCP
Trends in Benzodiazepine Prescribing to Adults in the United States
Original Research

February 18, 2026

Between 2018 and 2022, annual benzodiazepine use by US adults decreased from 4.7% to 3.4%.
, , , et al
JCP
Effects of Extended Cannabis Abstinence in Comorbid PTSD and Cannabis Use Disorder
Original Research

February 18, 2026

Participants who achieved abstinence reported significantly greater reductions in total PTSD symptom severity and symptom count compared to those who did not.
, , , et al
PCC
Suicidal Mental Imagery in Suicide Attempters
Original Research

February 12, 2026

The relationship between depression, suicidality, and suicidal mental imagery suggests that addressing imagery could be important for treatment and prevention.
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JCP
Postmarketing Safety of Transcranial Magnetic Stimulation: A 10-Year MAUDE Database Analysis
Original Research

February 11, 2026

This study addresses a key postmarket gap by analyzing real-world TMS adverse event reports from the MAUDE database.
, , , et al
JCP
Latency to LAI Antipsychotic Initiation and Psychiatric Hospitalization in First-Episode Schizophrenia
Original Research

February 9, 2026

Although delayed initiation was linked to better treatment adherence, early LAI use reduced hospitalization in first-episode patients.
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JCP
Unwanted Intrusive Thoughts of Infant-Related Sexual Harm
Original Research

February 4, 2026

Unwanted intrusive thoughts (UITs) of infant-related sexual harm were reported by 9.2% of participants. There was no association between these UITs and sexual behavior toward one’s infant.
, , , et al
PCC
Daylight Duration and rTMS Outcomes in Treatment-Resistant Depression
Original Research

February 3, 2026

The authors examine the possible impact of daylight duration during the course of repetitive transcranial magnetic stimulation on its efficacy in patients with treatment-resistant depression.
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