The Primary
Care Companionfor CNS Disorders

Volume 27 • 2025 • 5

Narrative Review

Toward Precision Psychiatry: Innovations and Prospects in Treating Depression

Prim Care Companion CNS Disord 2025;27(5):25nr03970

Daphna Laifenfeld, PhD; Claudia Albeldas, MSc; Talia Cohen Solal, PhD; Roger S. McIntyre, MD, FRCPC; Stephen Stahl, MD PhD

Narrative Review

Quality Improvement in Community Mental Health Care

Prim Care Companion CNS Disord 2025;27(5):25nr03962

Vishnu Mangalamchery, MPH; M. Vaseel, DNB; N. A. Uvais, MBBS, DPM, FRSPH, FRSB

Narrative Review

Incretin Therapies: A New Tool to Combat Metabolic Consequences of Antipsychotic Use

Prim Care Companion CNS Disord 2025;27(5):25nr03924

Amre A. Elmaoued, PharmD, PhC, BCPP; Raechel T. White, PharmD, PhC, BCACP

Original Research

Barriers and Facilitators to Accessing Primary Care in Patients With First-Episode Psychosis

Prim Care Companion CNS Disord 2025;27(5):25m03974

Alison R. Swigart, MD; Lauren J. Van Scoy, MD; Radha Dhingra, MD, PhD; Candace Bordner, MS; Heather J. Costigan, BS; Heather Stuckey-Peyrot, DEd

Original Research

Cognitive Distortions in Physician Guilt: Gaining Insight and Enhancing Wellness Through Media

Prim Care Companion CNS Disord 2025;27(5):24m03905.

Vincent Zhang, MD, MPH; Allison Dinar, MD; Fauzia Arain, MD; Douglas J. Opler, MD

Original Research

Impact of the COVID-19 Pandemic on the Mental Health of Middle-Aged and Older Adults: A Cross-Sectional, Comparative Study

Prim Care Companion CNS Disord 2025;27(5):25m03963

Preethy Kathiresan, DM; Shanaya Rathod, DM; Yatan Pal Singh Balhara, MD; Peter Phiri, PhD; Rachna Bhargava, PhD

Rounds in the General Hospital

Choosing a Pharmacologic Strategy for Those With a Psychotic Illness: Balancing Efficacy, Tolerability, and Cost

Prim Care Companion CNS Disord 2025;27(5):25f03983

Carol S. Lim, MD; Alejandra Morfin Rodriguez, MD; Abigail L. Donovan, MD; Sarah Maclaurin, PMHNP; Nicholas O. Daneshvari, MD; Theodore A. Stern, MD

Rounds in the General Hospital

Somatic Delusions: An Approach to Diagnosis and Treatment

Prim Care Companion CNS Disord 2025;27(5):25f03990

James K. Rustad, MD; Andrea C. DeSimone, DO; Zachary S. Goodman, MD; Patrick A. Ho, MD; Rebecca Schwartz, MD; Diana H. Li, DO; Anne Felde, MD; Scott Rebhun, MD; Robert Powell, DO; Theodore A. Stern, MD

Rounds in the General Hospital

The Impact of Relative and Absolute Hypotension on Cognitive Function

Prim Care Companion CNS Disord 2025;27(5):25f03997

Michalla B. Braford, DO; Jennifer Li, MD; Benjamin J. Hoover, MD; Theodore A. Stern, MD

Rounds in the General Hospital

Talking to Your Patients About Hematopoietic Stem Cell Transplantation: A Guide for Primary Care Providers

Prim Care Companion CNS Disord 2025;27(5):25f03968

Jeong Hoo Lee, MD; Hermioni L. Amonoo, MD, MPP, MPH; Anna Barata, PhD; Jamie M. Jacobs, PhD; Theodore A. Stern, MD

Rounds in the General Hospital

Antihistamines: Indications, Interactions, and Adverse Effects

Prim Care Companion CNS Disord 2025;27(5):25f03958

Matthew Gunther, MD; Austin Valido, BA; Shixie Jiang, MD; Theodore A. Stern, MD

Rounds in the General Hospital

Dizziness: An Approach to Diagnosis and Treatment

Prim Care Companion CNS Disord 2025;27(5):25f03967

James K. Rustad, MD; Michalla Braford, DO; Elyse Nguyen, MD; Lynne Boone, DO; Jacob Weber, MD; Shannon Ford, MD; Theodore A. Stern, MD

Case Report

When a Headache Isn’t Just a Headache: Ibuprofen-Related Aseptic Meningitis

Prim Care Companion CNS Disord 2025;27(5):25cr03991

Ananya Narasimhan, BS; Ishani Deshpande, BS; Pavan Kumar Reddy Kalluru, MD; Rachel Vattadi, MD; Andrieu Aguinaldo, MD; Antonio Topacio, MD

Case Report

Mosaic Turner Syndrome and Treatment-Resistant Schizophrenia

Prim Care Companion CNS Disord 2025;27(5):25cr03980

Mayank Gupta, MD; Vanessa C. D’Souza, MD; Leslie Citrome, MD, MPH

Case Report

Using N-Acetylcysteine as a Treatment for Psychogenic Polydipsia

Prim Care Companion CNS Disord 2025;27(5):25cr03993

Nickolas Daskalakis, BS; Genevieve Miller, MD; Brieanne Jungels, MD; Larrilyn Grant, MD; Richard Sanders, MD

Case Report

Secondary Trigeminal Neuralgia Due to Multiple Sclerosis in a Patient With Opioid Use Disorder Treated With Buprenorphine/Naloxone

Prim Care Companion CNS Disord 2025;27(5): 25cr03985.

David R. Spiegel, MD; Janelle Milstead, DO; Rebecca Fetter, BA; Gwendolyn George, BS; Ca Nguyen, BA; Zachary Lawrence, BS

Case Report

Incubus Syndrome in a Man With Alcohol Dependence

Prim Care Companion CNS Disord 2025;27(5):25cr03989

Tanvi Mittal, MBBS; Nishanth Jalaja Haridas, MD

Case Report

Development of Neuroleptic Malignant Syndrome After Administration of Clozapine and Electroconvulsive Therapy in a Patient With Schizophrenia

Prim Care Companion CNS Disord 2025;27(5):25cr04002

Kader Semra Karatas, MD

Case Report

Neuropsychiatric Challenges of Friedreich Ataxia in a Patient Residing in a Long-Term Care Facility

Prim Care Companion CNS Disord 2025;27(5):25cr03965.

Janeline Wong, MS; James Kwok, BS; Kye Kim, MD

Case Report

Fluoxetine-Induced Extrapyramidal Symptoms: A Rare Adverse Effect

Prim Care Companion CNS Disord 2025;27(5):25cr03996

Zoya Munsar, BS; Mariam Imtiaz, MBBS; Najeeb Hussain, MD

Case Report

Cerebrotendinous Xanthomatosis: Unraveling Prominent Neuropsychiatric Symptoms and Mild Cognitive Impairment With Subsequent Clinical Improvement

Prim Care Companion CNS Disord 2025;27(5):25cr04001

Abhijeet Anand, MBBS; Shobit Garg, MD, DPM; Mohan Dhyani, MD; Amrit Pattojoshi, MD, DPM

Case Report

Persistent Insomnia in an Elderly Man With HIV Receiving Dolutegravir-Based Antiretroviral Therapy

Prim Care Companion CNS Disord. 2025;27(5):25cr03992

Eleonora Krasniak, MD; Eloïse Magnenat, MD; Bernard Surial, PD, MD; Jacob Lahr, PD, MD

Case Report

Management of Neurobehavioral Symptoms Associated With Machado-Joseph Disease

Prim Care Companion CNS Disord. 2025;27(5):25cr03955

Collin Tanchanco, BS; Janeline Wong, MS; Kye Kim, MD

Case Report

Long-Term Nonprescription Use of Dexamethasone and Cyproheptadine With Metabolic and Endocrine Sequelae

Prim Care Companion CNS Disord 2025;27(5):25cr04008

Gurveen Kaur, MD; Vinit Patel, DM; Piyali Mandal, MD; Alok Agrawal, MD; Prabhu Dayal, MD; Atul Ambekar, MD

Case Report

Two Cases of Sodium Valproate and Valproic Acid–Induced Hypermelanosis

Prim Care Companion CNS Disord 2025;27(5):25cr03987

Mrinmoy Sarkar, MBBS; Arya Sundar Kamila, MBBS; Aniruddha Mukherjee, MD; Sourav Khanra, MD

Case Report

Management of Neuropsychiatric Symptoms Associated With Morquio Syndrome

Prim Care Companion CNS Disord 2025;27(5):25cr03988

Grace L. Casado, MS; Maedot A. Haymete, BA; Darlon Jan, MD; Kye Y. Kim, MD

$Electroconvulsive Therapy for Refractory Auditory Hallucinations in Turner Syndrome$

Case Report

Electroconvulsive Therapy for Refractory Auditory Hallucinations in Turner Syndrome

Prim Care Companion CNS Disord 2025;27(5):25cr03986

Nicholas S. McDuffee, MA, BS; Aren A. Forster, BA; Kaushal Shah, MD, MPH, MBA

Case Report

Amnesia Associated With Recreational Cannabis Use in an Adolescent

Prim Care Companion CNS Disord 2025;27(5):23cr03562

Kaushal Shah, MD; Sushma Srinivas, MD; Sahar Ashraf, MD; Faisal Kagadkar, MD; Dhwani Kamrai, PharmD; Shailesh Jain, MD

Case Report

Imipramine-Induced Catatonia in a Patient With Primary Nocturnal Enuresis and Emerging Bipolar Affective Disorder

Prim Care Companion CNS Disord 2025;27(5):25cr03961

Tanvi Mittal, MBBS; Nishanth Jalaja Haridas, MD

Case Report

Navigating Bell’s Mania and Catatonia: The Role of Electroconvulsive Therapy in Adolescent Psychiatry

Prim Care Companion CNS Disord 2025;27(5):25cr03953

Aren A. Forster, BA; Nicholas S. McDuffee, MA, BS; Kaushal Shah, MD, MPH, MBA; Preston Easterday, MD

Letter to the Editor

Knowledge of Electroconvulsive Therapy for Treatment of Catatonia

Prim Care Companion CNS Disord 2025;27(5):25lr04006

Randall T. Espinoza, MD, MPH; Charles H. Kellner, MD

Letter to the Editor

Brain Injuries, Illness, and Treatment in Sports: It’s Not All in the Mind

Prim Care Companion CNS Disord 2025;27(5):25lr04032

Ira D. Glick, MD; Malte C. Claussen, MD

Letter to the Editor

Complicated Grief: Is There a Role for Naltrexone?

Prim Care Companion CNS Disord 2025;27(5):25lr03981

Vania Modesto-Lowe, MD; Jasleen Kaur, MD

Letter to the Editor

What Internists and Neurologists Know and Think About Catatonia: Reply to Espinoza and Kellner

Prim Care Companion CNS Disord 2025;27(5):25lr04006a

Japsimran Kaur, MD; Daniel D. Maeng, PhD; Joshua Wortzel, MD, MPhil, MS; Mark A. Oldham, MD

Volume 27 • 2025 • 5

Narrative Review

Toward Precision Psychiatry: Innovations and Prospects in Treating Depression

Quality Improvement in Community Mental Health Care

Incretin Therapies: A New Tool to Combat Metabolic Consequences of Antipsychotic Use

Original Research

Barriers and Facilitators to Accessing Primary Care in Patients With First-Episode Psychosis

Cognitive Distortions in Physician Guilt: Gaining Insight and Enhancing Wellness Through Media

Impact of the COVID-19 Pandemic on the Mental Health of Middle-Aged and Older Adults: A Cross-Sectional, Comparative Study

Rounds in the General Hospital

Choosing a Pharmacologic Strategy for Those With a Psychotic Illness: Balancing Efficacy, Tolerability, and Cost

Somatic Delusions: An Approach to Diagnosis and Treatment

The Impact of Relative and Absolute Hypotension on Cognitive Function

Talking to Your Patients About Hematopoietic Stem Cell Transplantation: A Guide for Primary Care Providers

Antihistamines: Indications, Interactions, and Adverse Effects

Dizziness: An Approach to Diagnosis and Treatment

Case Report

When a Headache Isn’t Just a Headache: Ibuprofen-Related Aseptic Meningitis

Mosaic Turner Syndrome and Treatment-Resistant Schizophrenia

Using N-Acetylcysteine as a Treatment for Psychogenic Polydipsia

Secondary Trigeminal Neuralgia Due to Multiple Sclerosis in a Patient With Opioid Use Disorder Treated With Buprenorphine/Naloxone

Incubus Syndrome in a Man With Alcohol Dependence

Development of Neuroleptic Malignant Syndrome After Administration of Clozapine and Electroconvulsive Therapy in a Patient With Schizophrenia

Neuropsychiatric Challenges of Friedreich Ataxia in a Patient Residing in a Long-Term Care Facility

Fluoxetine-Induced Extrapyramidal Symptoms: A Rare Adverse Effect

Cerebrotendinous Xanthomatosis: Unraveling Prominent Neuropsychiatric Symptoms and Mild Cognitive Impairment With Subsequent Clinical Improvement

Persistent Insomnia in an Elderly Man With HIV Receiving Dolutegravir-Based Antiretroviral Therapy

Management of Neurobehavioral Symptoms Associated With Machado-Joseph Disease

Long-Term Nonprescription Use of Dexamethasone and Cyproheptadine With Metabolic and Endocrine Sequelae

Two Cases of Sodium Valproate and Valproic Acid–Induced Hypermelanosis

Management of Neuropsychiatric Symptoms Associated With Morquio Syndrome

Electroconvulsive Therapy for Refractory Auditory Hallucinations in Turner Syndrome

Amnesia Associated With Recreational Cannabis Use in an Adolescent

Imipramine-Induced Catatonia in a Patient With Primary Nocturnal Enuresis and Emerging Bipolar Affective Disorder

Navigating Bell’s Mania and Catatonia: The Role of Electroconvulsive Therapy in Adolescent Psychiatry

Letter to the Editor

Knowledge of Electroconvulsive Therapy for Treatment of Catatonia

Brain Injuries, Illness, and Treatment in Sports: It’s Not All in the Mind

Complicated Grief: Is There a Role for Naltrexone?

What Internists and Neurologists Know and Think About Catatonia: Reply to Espinoza and Kellner

Expert Consensus on Aripiprazole LAIs in Clinical Practice

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