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The Primary
Care Companionfor CNS Disorders
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Primary Care Companion for CNS Disorders

Diary From the Front Lines August 15, 2005

Irritable? I'll Show You Irritable!

Prim Care Companion J Clin Psychiatry 2005;7(4):200-201

Article Abstract
Diary From the Front Lines Irritability

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New Series The JCP Podcast Lamotrigine clearance can rise by 200% to 300% in pregnancy, turning a previously stable dose into therapeutic failure, while the postpartum reset can make that same dose toxic fast. This conversation gets practical about monitoring, tapering, and why screening for bipolar disorder in postpartum depression can change treatment decisions.

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The Primary Care Companion journal cover featuring psychiatric research articles

Vol 28 • 2026 • Number 3

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