The Primary
Care Companionfor CNS Disorders

Volume 28 • 2026 • 5

Narrative Review

Skin and Brain in Bipolar Disorder: A Review of Dermatologic-Psychotropic Drug Interactions

Prim Care Companion CNS Disord.2026;28(5):26nr04252.

Drew Mack, BS; Nina Modanlo, MHS; Ingyun Park, BS; Xiaofeng Yan, MD, PhD; James Alan Bourgeois, OD, MD

Narrative Review

Clinical Recognition and Management of Catatonia: A Practical Guideline and Treatment Algorithm

Prim Care Companion CNS Disord 2026;28(5):26nr04231

Namratha Mohan, MBA; Ashish Sarangi, MD

Original Research

Association of Intrusive Posttraumatic Stress Symptoms With Elevated C-Reactive Protein Levels in World Trade Center Responders

Prim Care Companion CNS Disord 2026;28(5):25m04177

Sarah B. Rutter, MA; Abigail B. Collins, BS; Marin Kautz, PhD; Leo M. Cancelmo, PhD; Olivia Diab, JD; Leah Cahn, LCSW; Cindy Aaronson, PhD; Jamie Schaffer, PsyD; Nicoló Cipriani, MD; Clyde Schechter, MD; Linda M. Bierer, MD; Michael Crane, MD, MPH; Jacqueline M. Moline, MD; Iris G. Udasin, MD; Denise J. Harrison, MD; Rachel Yehuda, PhD; Sarah R. Horn, MA; Robert H. Pietrzak, PhD, MPH; Adriana Feder, MD

Original Research

Patient Perspectives on Long-Acting Injectable Medications During Psychiatric Hospitalization

Prim Care Companion CNS Disord 2026;28(5):26m04258

Tanya Alim, MD; Allea Frazier, MPH; Michelle Brooks, PharmD; Stephanie A. Rolin, MD, MPH

Original Research

Bilateral Transcranial Direct-Current Stimulation Over the Dorsolateral Prefrontal Cortex Significantly Reduces Relief Craving During Alcohol Withdrawal: A Randomized Sham-Controlled Trial Among Inpatients With Alcohol Dependence Syndrome in Northern India

Prim Care Companion CNS Disord 2026;28(5):26m04219

Twinkle Sharma, MD; Priya Ranjan Avinash, MD, DPM; Robin Victor, MD; Praveen Rikhari, MD; Shobit Garg, MD, DPM

Original Research

Vision Care Pathway Measures and Vision Outcomes in US Children With Mental, Emotional, Developmental, or Behavioral Problems: National Survey of Children’s Health 2019–2023

Prim Care Companion CNS Disord 2026;28(5):26m04278

Juan M. Riestra, BS; Sedra T. Alabed, BS; Diana B. Riestra, BS; Mustafa Jaffry, MD; Suqin Guo, MD; Prashanth Iyer, MD; Bernard C. Szirth, PhD; Albert S. Khouri, MD; Najeeb U. Hussain, MD

Academic Highlights

Academic Highlights ▶ Video

Targeted Treatment of Agitation in Alzheimer’s Dementia: Prioritizing Function and Safety Over Sedation and Other Serious Harms

Prim Care Companion CNS Disord 2026;28(5):PCC.haadachi2603

Pierre N. Tariot, MD; Leslie Citrome, MD, MPH; Carolyn K. Clevenger, DNP, GNP; W. Clay Jackson, MD, DipTh; C. Brendan Montano, MD; Amita Patel, MD; Anton P. Porsteinsson, MD; Marwan Sabbagh, MD

Rounds in the General Hospital

Managing the Sequelae of Delirium Associated With Critical Illness

Prim Care Companion CNS Disord.2026;28(5):26f04249

Joseph D. Dragonetti, MD; Maureen K. Cassady, MD; Emma R. Torncello, MD; Sydney P. Williams, BA; Hunter G. Shelton, DO; Zachary E. Bean, MD; Alejandro E. Rodulfo, MD; Dina Soliman, MD; Theodore A. Stern, MD

Rounds in the General Hospital

Rectal Insertion of Foreign Bodies: Motivations, Complications, and Management

Prim Care Companion CNS Disord 2026;28(5):26f04248

Ann C. Schwartz, MD; Gregg Robbins-Welty, MD, MS, HEC-C; Caroline Stiles, PsyD; Theodore A. Stern, MD

Rounds in the General Hospital

When Hair Becomes Hazardous: Trichotillomania, Trichophagia, and Gastric Trichobezoar

Prim Care Companion CNS Disord 2026;28(5):26f04254

Ann C. Schwartz, MD; Gregg Robbins-Welty, MD, MS, HEC-C; Theodore A. Stern, MD

Rounds in the General Hospital

Practicing in Resource-Limited and Siloed Settings: The Impact of Isolation on Morale, Clinical Care, and Lifelong Learning

Prim Care Companion CNS Disord 2026;28(5):26f04247

Sofia E. Matta, MD; Julian J. Raffoul, MD, PhD; Lynne Boone, DO; Andrea C. DeSimone, DO; Margarita Bobonis-Babilonia, MD; Ann C. Schwartz, MD; Theodore A. Stern, MD

Rounds in the General Hospital

The Aftermath of Risking Life and Limb: Acute Reactions and Subsequent Adaptation

Prim Care Companion CNS Disord 2026;28(5):26f04215

Daniel Powell, MD; Tyler McGehee, MD; David Wilkerson, DO; Gregg Robbins-Welty, MD, MS, HEC-C; Brendan Appold, MD; Jacob MacDonald, MD; James K. Rustad, MD; Theodore A. Stern, MD

Rounds in the General Hospital

Reactions to, and Coping With, the Sequelae of Medical Errors That Lead to Disfigurement and Loss of Function

Prim Care Companion CNS Disord 2026;28(5):26f04216

Daniel Powell, MD; David Wilkerson, DO; Gregg Robbins-Welty, MD, MS, HEC-C; James K. Rustad, MD; Theodore A. Stern, MD

Rounds in the General Hospital

Relaxation, Guided Imagery, Willful Dissociation, and Hypnosis: Practical Strategies for Primary Care Providers

Prim Care Companion CNS Disord. 2026;28(5):26f04222

Philip R. Muskin, MD; Jose R. Maldonado, MD; Joseph D. Dragonetti, MD; Theodore A. Stern, MD

Case Report

Forty Years of Untreated Anorexia Nervosa: How Bad Can It Get?

Prim Care Companion CNS Disord 2026;28(5):26cr04240

Joana Romão, MD; Marta Rebelo, MD; Patrícia Baronet, MD; Rita André, MD; Tiago Duarte, MD

Case Report

Artificial Intelligence–Associated Psychosis

Prim Care Companion CNS Disord 2026;28(5):26cr04260

Jamie Harbourd, MD; Suresh Yadav, MD, FRANZCP; Kagan Temur, MD; Sandeep Grover, MD, FRANZCP

Case Report

Atypical Depression: A Clinical Alert for Obstructive Sleep Apnea Screening

Prim Care Companion CNS Disord 2026;28(5):26cr04237

Ana Lourenço, MD; Marta Ribeiro, MD

Case Report

When the Therapist’s Thoughts Change, the Patient Changes: An Intervention for Adolescent Patients Who Discontinue Psychotherapy Based on a Buddhist Concept

Prim Care Companion CNS Disord 2026;28(5):26cr04227

Takuji Inagaki, MD, PhD

Case Report

Early Palliative Care and Structured Serious Illness Communication in a Refugee Patient With Amyotrophic Lateral Sclerosis

Prim Care Companion CNS Disord 2026;28(5):26cr04223

Jillian Rankin, BS; Carina Oltmann, LCSW; Emily Pinto Taylor, MD; Daniel Schachter, MD; Ashima Lal, MD

Case Report

Limb Loss After Intentional Dry Ice Frostbite in a Patient With Body Integrity Dysphoria and the Role of Online Identity Communities

Prim Care Companion CNS Disord 2026;28(5):26cr04277.

Ann C. Schwartz, MD, FACLP; Gregg A. Robbins-Welty, MD, MS, HEC-C; Caroline Stiles, PsyD; Nancy Gimbel, PhD; Nadine J. Kaslow, PhD, ABPP; Laura S. Johnson, MD, FACS, FCCP, FCCM; Bao Chau Ly, MD; Sarah E. Dunn, PhD, ABPP

Case Report

Use of Electroconvulsive Therapy and Ketamine in a POLG-Related Disorder

Prim Care Companion CNS Disord 2026;28(5):26cr04238

Sina Hafizi, MD; Vishal Kaushik, MD; Reece Ramkissoon, MD

Case Report

Acute Psychosis and Delirium During Menstruation in a Premenopausal Woman With Urinary Tract Infection

Prim Care Companion CNS Disord 2026;28(5):26cr04300.

Sara Ellias, MS; Aateqa Hashmi, MD; Jisselly Sanchez Salcedo, MD; Kayleigh Watson, MD

Case Report

Vintage Find, Modern Emergency: Unexpected Methaqualone Ingestion in an Adolescent

Prim Care Companion CNS Disord 2026;28(5):26cr04274

Patrick L. Tomlinson, MSN, CPNP-AC; Nasuh Malas, MD, MPH

Case Report

Butorphanol Dependence in a Woman With No Prior Substance Use

Prim Care Companion CNS Disord 2026; 28(5):26cr04253.

Jadeer K. Muhammed, MD; Piyali Mandal, MD; Atul Ambekar, MD

Case Report

Bound for Calmness: Voluntary Rope-Tying Behavior in Late-Life Generalized Anxiety Disorder

Prim Care Companion CNS Disord 2026;28(5):26cr04280.

Om Prakash, MD; Shreyashi Koner, MD; Amit Khanna, MD; Mustafa Ali, MD; Muskan Bansal, MBBS

Case Report

Acute Onset of Mood and Psychotic Symptoms After Rapid Discontinuation of a GLP-1 Agonist

Prim Care Companion CNS Disord 2026;28(5):26cr04314.

Corey Horien, MD, PhD; John Curran, MD; Emily Sudhakar, MD; Jared Ellman, MD

Case Report

Serotonin Syndrome After Kratom Use in a Patient on a Stable Psychotropic Regimen

Prim Care Companion CNS Disord 2026;28(5):26cr04244

Talya Kapenstein, MD; Alëna A. Balasanova, MD

Case Report

Esketamine For the Treatment of Depression in a Patient With Multiple Sclerosis

Prim Care Companion CNS Disord 2026;28(5):26cr04246

Meghna Mathews, MD; Genesy Aickareth, MD; Anjal Abraham, BS; Rucha Kamat, BS; Rahul Mathews; Brett Pontelandofo, BS; Shreya Mathews; Kelly Golden, APN

Case Report

Olfactory Reference Syndrome Responding to Amisulpride

Prim Care Companion CNS Disord 2026;28(5):26cr04191

João Revez Lopes, MD; Carlos Siopa, MD; Inês Simões, MD

Case Report

When Obsession and Psychosis Become Indistinguishable: A Clinical Case Report

Prim Care Companion CNS Disord 2026;28(5):26cr04228

Marta Rebelo, MD; Patrícia Baronet, MD; José Abrantes, MD; Marta Croca, MD

Case Report

Resurrecting Voice: Role of Lorazepam in Chronic Catatonia Reversal

Prim Care Companion CNS Disord 2026;28(5):26cr04217

G. Shreya Eashwar, MBBS; Lokesh Kumar Singh, MD; Namish Kumar, MD

Letter to the Editor

Psychedelics in Psychiatry: A Wakeup Call for Clinicians in the Age of Policy Reform

Prim Care Companion CNS Disord. 2026;28(5):26lr04256

Shobit Garg, MD, DPM; Amrit Pattojoshi, MD, DPM

Volume 28 • 2026 • 5

Narrative Review

Skin and Brain in Bipolar Disorder: A Review of Dermatologic-Psychotropic Drug Interactions

Clinical Recognition and Management of Catatonia: A Practical Guideline and Treatment Algorithm

Original Research

Association of Intrusive Posttraumatic Stress Symptoms With Elevated C-Reactive Protein Levels in World Trade Center Responders

Patient Perspectives on Long-Acting Injectable Medications During Psychiatric Hospitalization

Bilateral Transcranial Direct-Current Stimulation Over the Dorsolateral Prefrontal Cortex Significantly Reduces Relief Craving During Alcohol Withdrawal: A Randomized Sham-Controlled Trial Among Inpatients With Alcohol Dependence Syndrome in Northern India

Vision Care Pathway Measures and Vision Outcomes in US Children With Mental, Emotional, Developmental, or Behavioral Problems: National Survey of Children’s Health 2019–2023

Academic Highlights

Targeted Treatment of Agitation in Alzheimer’s Dementia: Prioritizing Function and Safety Over Sedation and Other Serious Harms

Rounds in the General Hospital

Managing the Sequelae of Delirium Associated With Critical Illness

Rectal Insertion of Foreign Bodies: Motivations, Complications, and Management

When Hair Becomes Hazardous: Trichotillomania, Trichophagia, and Gastric Trichobezoar

Practicing in Resource-Limited and Siloed Settings: The Impact of Isolation on Morale, Clinical Care, and Lifelong Learning

The Aftermath of Risking Life and Limb: Acute Reactions and Subsequent Adaptation

Reactions to, and Coping With, the Sequelae of Medical Errors That Lead to Disfigurement and Loss of Function

Relaxation, Guided Imagery, Willful Dissociation, and Hypnosis: Practical Strategies for Primary Care Providers

Case Report

Forty Years of Untreated Anorexia Nervosa: How Bad Can It Get?

Artificial Intelligence–Associated Psychosis

Atypical Depression: A Clinical Alert for Obstructive Sleep Apnea Screening

When the Therapist’s Thoughts Change, the Patient Changes: An Intervention for Adolescent Patients Who Discontinue Psychotherapy Based on a Buddhist Concept

Early Palliative Care and Structured Serious Illness Communication in a Refugee Patient With Amyotrophic Lateral Sclerosis

Limb Loss After Intentional Dry Ice Frostbite in a Patient With Body Integrity Dysphoria and the Role of Online Identity Communities

Use of Electroconvulsive Therapy and Ketamine in a POLG-Related Disorder

Acute Psychosis and Delirium During Menstruation in a Premenopausal Woman With Urinary Tract Infection

Vintage Find, Modern Emergency: Unexpected Methaqualone Ingestion in an Adolescent

Butorphanol Dependence in a Woman With No Prior Substance Use

Bound for Calmness: Voluntary Rope-Tying Behavior in Late-Life Generalized Anxiety Disorder

Acute Onset of Mood and Psychotic Symptoms After Rapid Discontinuation of a GLP-1 Agonist

Serotonin Syndrome After Kratom Use in a Patient on a Stable Psychotropic Regimen

Esketamine For the Treatment of Depression in a Patient With Multiple Sclerosis

Olfactory Reference Syndrome Responding to Amisulpride

When Obsession and Psychosis Become Indistinguishable: A Clinical Case Report

Resurrecting Voice: Role of Lorazepam in Chronic Catatonia Reversal

Letter to the Editor

Psychedelics in Psychiatry: A Wakeup Call for Clinicians in the Age of Policy Reform

Insightful. Evidence-based. Human-centered.

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