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CME

Why Treat Insomnia?

Why Treat Insomnia?

CME Background

Articles are selected for credit designation based on an assessment of the educational needs of CME participants, with the purpose of providing readers with a curriculum of CME articles on a variety of topics throughout each volume. Activities are planned using a process that links identified needs with desired results.

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CME Objective

After studying this article, you should be able to:

  • Consider chronic insomnia to be a treatment target

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The CME Institute of Physicians Postgraduate Press, Inc., designates this educational activity for a maximum of 1.5 AMA PRA Category 1 Credits™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

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Objective: To make the case that insomnia is better conceptualized, not as a symptom, but as a primary disorder.

Data Sources: PubMed was searched from 1975-2009 using the search terms insomnia, insomnia and treatment, insomnia and cost, and insomnia and treatment and safety.

Study Selection: English-language articles and other materials were selected to address the following claims: insomnia is unremitting, insomnia is disabling, insomnia is costly, insomnia is pervasive, insomnia is pernicious, and insomnia treatment is safe and effective.

Data Extraction/Synthesis: Insomnia, at least when chronic, should be conceptualized as a comorbid condition, one for which effective interventions are available.

Conclusions: It is speculated that treatment for insomnia will only become the norm when it has been demonstrated that treatment not only addresses the problem of insomnia but also serves to reduce medical and psychiatric morbidity. At that time, the question will no longer be “Why treat insomnia?” but instead “When isn’ t insomnia treatment indicated?”

Prim Care Companion J Clin Psychiatry 2010;12(1):e1-e9

Submitted: November 11, 2008; accepted March 6, 2009.

Published online: February 25, 2010 (doi:10.4088/PCC.08r00743bro).

Corresponding author: Michael L. Perlis, PhD, Behavioral Sleep Medicine Program, Department of Psychiatry, University of Pennsylvania, Suite 670, 3535 Market St, Philadelphia, PA 19104 (mperlis@mail.med.upenn.edu).

For several decades beginning in the 1970s, insomnia was considered a “symptom” not a “disorder.” To the extent that insomnia was considered just a symptom of medical or psychiatric disease, it was believed that treatment of the parent disorder was sufficient and would result in the resolution of the insomnia. More recently, this perspective has given way to the position that, when chronic, insomnia should be characterized as a primary disorder, which, when it co-occurs with other medical and psychiatric illness, should be designated a comorbid condition (as opposed to a secondary symptom). These nosologic designations carry with them the clear implication that chronic insomnia merits targeted treatment. This perspective, however, has yet to influence the standard of practice. More often than not, insomnia continues to be undiagnosed and/or untreated.

In the present article, we attempt to answer the question: Why treat insomnia? PubMed was searched for English-language articles from 1975-2009 using the search terms insomnia, insomnia and treatment, insomnia and cost, and insomnia and treatment and safety.

Insomnia, when chronic, tends to be unremitting, disabling, costly, pervasive, and pernicious. These factors, in combination with the existence of effective treatments, provide more than sufficient justification for the perspective that insomnia should be a primary focus for treatment.

INSOMNIA IS UNREMITTING

There are very few studies on the natural history of insomnia. To our knowledge, there are a handful of such investigations.1-5 In general, these studies find that chronic insomnia does not spontaneously resolve,1,3,5 and the presenting form of insomnia (ie, initial, middle, or late) tends to be unstable or variable over time. With respect to spontaneous remission, Mendelson1 found that subjects who reported difficulty sleeping at their initial assessment (average chronicity of 10 years) continued to report insomnia at 2 follow-up intervals (70% at 40 months and 88% at 64 months) (Figure 1).

Figure 1

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INSOMNIA IS DISABLING

To date, there are a number of investigations that suggest that individuals with chronic insomnia, as opposed to no or occasional insomnia, have more difficulty with intellectual, social, and/or vocational functioning (Figure 2).

Figure 2

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With respect to intellectual functioning, there are numerous studies6-8 documenting that patients with chronic insomnia report impaired cognitive performance. In fact, this type of daytime complaint constitutes one of the defining attributes of insomnia as it is delineated in The International Classification of Sleep Disorders, Second Edition.9 This said, neuropsychological evaluations of patients with chronic insomnia have not yielded reliable data regarding specific cognitive deficits.10 This discrepancy between perceived and measured impairment may be reflective of several things.

Clinical Points

  • Insomnia is best conceptualized as a disorder (as opposed to a symptom)
  • When insomnia occurs along with other disorders, it is best conceptualized as a comorbid disorder
  • Benzodiazepine receptor agonists and cognitive-behavioral therapy for insomnia (CBT-I) are effective to treat insomnia in the short term, and CBT-I has effects that persist beyond treatment discontinuation
  • Targeted treatment of insomnia may serve to diminish the severity of disorders that are comorbid with the insomnia
  • The primary barrier to successful treatment of insomnia is the relative unavailability of CBT-I providers

First, there may be an attentional bias toward negative performance, which nevertheless occurs at a normal rate.11,12 Second, a neurotic preoccupation with poor performance irrespective of whether or not it occurs may be present. Third, and finally, the perception of performance deficits may not be related to actual poor performance, or altered self-monitoring, but rather to the patient’s real appreciation of the fact that extra effort is required to maintain normal or near-normal performance.10

With respect to social functioning, patients with chronic insomnia reliably report decreased interest in, facility with, and satisfaction from interpersonal relationships and social interactions. For example, in patients being seen in a primary care practice, chronic insomnia is associated with decreased ability to handle minor irritations, decreased ability to enjoy family/social life, and poorer interpersonal relationships with spouses.8

With respect to vocational performance, several studies have found that sleep disturbance and/or chronic insomnia are associated with less job satisfaction, lower performance scores, less productivity, and higher rates of absenteeism.13,14 A study by Leger et al15 found that those with insomnia had more absenteeism compared to good sleepers (31% vs 19%) and made more errors at work in the previous month (15% vs 6%) and that 18% of those with insomnia, versus 8% of good sleepers, reported poor work efficiency in the past month.

INSOMNIA IS COSTLY

In the United States alone, the direct and indirect costs attributable to insomnia exceed $100 billion annually.16 Direct costs, including physician visits, prescriptions, and procedures, equal or exceed $13 billion per annum.17 These costs are, in part, related to the increased tendency of patients with insomnia to use health care resources and to the costs of pharmacotherapy.15 The estimated cost of physician visits is over $600 million per year, and the cost of prescription medications is estimated to be over $800 million per year.17

Indirect costs associated with motor vehicle and workplace accidents, reduced productivity, and absenteeism are thought to account for the majority of the economic consequences of insomnia with cost estimates between $77 and $92 billion per annum. Individuals with a variety of sleep disorders are thought to be at increased risk for motor vehicle accidents.18 Patients with insomnia in particular have been found to be 2½ times more likely to report car crashes because of feeling tired as compared to those who do not report insomnia.19

One study in an Australian cohort estimated the cost of sleep-related motor vehicle accidents to be in excess of $180 million per year (Australian $).20 Patients with insomnia are also thought to be at increased risk for workplace accidents (industrial accidents). In the Australian cohort, it was found that patients with insomnia were approximately 8 times more likely to have such accidents as compared to good sleepers. In this instance, the annual cost of work place accidents was estimated to be in excess of $1.9 billion (Australian $).20 Finally, as noted above, insomnia is associated with reduced productivity and absenteeism. These costs have been estimated to exceed 1.3 billion per annum (Australian $).20

Figure 3

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Figure 4

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The aforementioned direct and indirect costs were assessed at the societal level. Recent work by Ozminkowski et al21 suggests that the individual cost per annum among patients with insomnia is $1,253 in younger adults and $1,143 in older adults more than the direct health care expenses of the same groups of patients without insomnia. Figure 3 provides further cost data.

INSOMNIA IS PERVASIVE

As stated in the 2005 National Institutes of Health (NIH) State-of-the-Science Conference Statement on Manifestations and Management of Chronic Insomnia in Adults:22

. . . chronic insomnia is known to be common. Population-based studies suggest that about 30% of the general population complains of sleep disruption, while approximately 10% has associated symptoms of daytime functional impairment consistent with the diagnosis of insomnia, although it is unclear what proportion of that 10% suffers from chronic insomnia. Not surprisingly, higher prevalence rates are found in clinical practices, wherein about half of respondents report symptoms of sleep disruption.

INSOMNIA IS PERNICIOUS

While it may seem an overstatement to say “insomnia is pernicious,” there are a variety of studies suggesting that chronic insomnia is a significant risk factor for both new-onset and recurrent medical and psychiatric illness.

With respect to medical disease, the data suggesting that insomnia confers risk are preliminary. Only a few epidemiologic studies have been conducted, and even fewer studies have assessed the association prospectively. This said, the data that exist suggest that patients with insomnia are more likely to suffer from pain conditions and gastrointestinal distress13 and that untreated insomnia puts sufferers at risk for hypertension23,24 and heart disease.23,25 It has also been suggested that insomnia may be a risk factor for the development of diabetes. Experimental data in good sleeper subjects have shown that sleep loss is associated with reduced insulin sensitivity.26 Observational data in patients with type II diabetes have shown that poor sleep quality is associated with poor glycemic regulation.27 Finally, there are data indicating that insomnia and/or short sleep duration are associated with increased mortality.28,29 Whether these associations are causal remains to be determined as does what factors related to insomnia in specific confer and moderate/mediate risk.

With respect to psychiatric disease, there is a preponderance of data to suggest that insomnia confers increased risk for new-onset and recurrent illness and that this is particularly true for depression/major depressive disorder (MDD).30 There are now at least 14 longitudinal studies showing that subjects with chronic insomnia are between 2 and 6 times more likely to have a new-onset or recurrent episode of depression (within 6 months to 3 years) as compared to subjects without chronic insomnia (Figure 4).31-44

In addition to the risk for new-onset and recurrent illness, there are 2 studies that suggest that insomnia is associated with the clinical course of MDD. In the first study,45 subjects with recurrent MDD were assessed to determine whether insomnia severity increases prior to recurrence of MDD (ie, whether insomnia exists as a prodromal or precipitating factor for MDD). The time series data from this study showed that the nonrecurrent group exhibited an elevated, but stable, level of insomnia, while the recurrent group exhibited an increased level of sleep disturbance that began 5 weeks prior to, and was of highest severity at, the week of recurrence.45

In the second study,46 the association of insomnia to treatment response was assessed in a large interventional study of late-life depression. Subjects were assessed for their clinical status at baseline and at 3, 6, and 12 months to determine whether insomnia at baseline and 3 months (classified as no insomnia, insomnia, and persistent insomnia) was associated with clinical improvement and/or the occurrence of remission at 6 and 12 months.46 The groups were found to be significantly different in terms of the percentage of subjects who remained ill at 6 months according to 2 measures of depression (remission and <50% improvement). Overall, patients with persistent insomnia were 2-4 times less likely to achieve remission or an improvement ≥50% in depressive symptoms as compared with patients with no insomnia.46

Taken together, these data suggest that insomnia may serve as a predisposing, precipitating, and/or perpetuating factor for depression. This said, as with medical disorders, it remains to be (1) shown that these associations are causal and (2) determined as to what factors related to insomnia confer and mediate risk. For additional information on the association between insomnia and depression, the reader is referred to Pigeon and Perlis30 and Perlis et al.47

INSOMNIA TREATMENT IS SAFE AND EFFECTIVE

There are a number of meta-analyses that summarize the literature for both benzodiazepines and benzodiazepine receptor agonists (BZRAs; ie, zolpidem, eszopiclone, and zaleplon) and for cognitive-behavioral therapy for insomnia (CBT-I).48-51 There is also 1 comparative meta-analysis that evaluates the relative efficacy of benzodiazepines and BZRAs as compared to CBT-I.52 The data from these studies suggest, consistent with the conclusions of the NIH State-of-the-Science Conference Statement,22 that (1) BZRAs and CBT-I are effective to treat insomnia in the short term, and CBT-I appears to have more durable effects when active treatment is discontinued, and (2) there is limited evidence that BZRAs retain their efficacy during long-term treatment.

As for safety, most agree that the first-line treatment modalities have very benign safety profiles. To date, only a few studies have been conducted on the relative safety of benzodiazepines and BZRAs, and no studies have been conducted comparing the efficacy and safety of medications with an indication for insomnia and/or CBT-I to medications that are used off label.

ARE THESE REASONS ENOUGH TO JUSTIFY TREATMENT?

The central proposition for this review is because chronic insomnia tends to be unremitting, disabling, costly, pervasive, and pernicious, and because there are effective treatments, there is more than sufficient justification for the perspective that insomnia should be a primary focus for treatment. While reasonable, this proposition does not address the issue that would eliminate any and all doubt about the appropriateness of aggressive treatment of insomnia: the possibility that insomnia is a modifiable risk factor for medical and psychiatric illness.

To date, all that can be definitively said is that insomnia treatment diminishes the severity of insomnia and/or the psychological distress that accompanies this disorder. While a laudable outcome, there is little information available regarding the daytime consequences of improved sleep. This is the case because treatment outcome has almost exclusively focused on the sleep continuity variables,53 and there is not yet a consensus regarding the criteria to determine what constitutes successful outcomes.54 What is needed are clear demonstrations that insomnia treatment reduces the incidence and severity of insomnia and that such outcomes serve to improve daytime function and/or reduce the incidence and severity of other forms of medical and psychiatric symptomatology and/or morbidity. To date, there are only a handful of such studies.

Within the daytime function arena, there are 3 studies that show that treatment positively impacts this domain. Leger and colleagues55 have shown that medical treatment of insomnia results in significant improvements with respect to quality of life. Krystal53 has shown that pharmacologic treatment results in improved self-reported health, mood, concentration/alertness, daytime functioning, and quality of life. Walsh and colleagues56 have shown similar gains with pharmacotherapy on quality of life measures and extend these findings to include positive outcomes with respect to work limitations.

Within the medical and psychiatric domain, there are 2 studies with medical outcomes and 3 investigations with psychiatric outcomes. With respect to medical outcomes, Edinger and colleagues57 found that CBT-I leads to improvements in medical and psychological functioning in patients with fibromyalgia. Preliminary data from Pigeon et al58 show that CBT-I in chronic pain patients with comorbid insomnia leads to significant reductions in insomnia, depression, and perceived pain (as measured by the Pain Disability Index and the Multidimensional Pain Inventory) as compared to patients who received nondirective-supportive therapy or were randomized to a wait-list condition.

With respect to psychiatric outcomes, Fava and colleagues59 have shown that concomitant treatment of insomnia in the context of acute depression (fluoxetine±eszopiclone) yields (1) effects on insomnia that are comparable with those seen in primary insomnia and (2) effects on the clinical course of the comorbid disorder. That is, a larger proportion of patients treated with dual therapy experienced treatment response and/or remission and did so at an accelerated rate. Similar preliminary data with CBT-I were recently reported by Manber et al.60 Finally, there is a study by Taylor and colleagues61 suggesting that CBT-I, when administered as a monotherapy, is associated with a significant decrease in depression severity in acutely ill patients with mild depression. Taken together, these data provide the first examples that insomnia treatment may improve quality of life and have larger effects on at least mental health.

CONCLUSION

Ultimately, the question “Why treat insomnia?” is derived from the broader question “Why bother treating insomnia?” The latter concept is rooted in the belief that insomnia is primarily only a symptom, is occasionally a primary disorder, and more often than not occurs secondary to other medical and psychiatric conditions. Implicit in this point of view is that (1) it is possible to, for the purposes of diagnosis, distinguish between primary and secondary insomnia; (2) when the primary condition is properly treated, the insomnia will (as a symptom of that primary disorder) abate; and (3) targeted treatments for primary insomnia will be relatively, or completely, ineffective for secondary insomnia (chronic insomnia that occurs in the context of, for example, depression, posttraumatic stress disorder, chronic pain, cancer, etc).

In recent years, there has been a growing interest in the veracity of the concept of secondary insomnia. This challenge has largely occurred at the theoretical level. Lichstein and colleagues62-65 have argued that it is nearly impossible to substantiate that insomnia is truly secondary (ie, that the onset of the insomnia co-occurred with the onset of, and temporally covaries with the severity of, the primary disorder), and, thus, the distinction has little nosological value and should not be used to dictate when targeted treatment is warranted. This point of view is further buttressed by the Spielman Model of Insomnia,66,67 which clearly suggests that chronic insomnia is maintained by a set of factors that function independently of what may have predisposed the individual to, or precipitated the acute episode of, insomnia. If this is true, the concept of secondary insomnia has little value beyond designating the factor that may have served to precipitate the insomnia.

Apart from the above theoretical considerations are the more practical tests of the concept that are related to treatment outcome. That is, “Is it really the case that, when the primary condition is properly treated, the insomnia abates?” Conversely, “Is it really the case that targeted treatments for primary insomnia are relatively, or completely, ineffective for secondary insomnia?”

In the case of the former question, there are few studies that evaluate the effects of treatment of primary conditions on the incidence and severity of insomnia. Of the investigations that exist, most (if not all) have been conducted in subjects with major depression. Reynolds et al,68 for example, found in subjects who were treated with nortriptyline and designated as “recovered” from depression, that their insomnia severity (as measured with the Pittsburgh Sleep Quality Index) was reduced but not normalized. In a similar study, Nierenberg et al69 found that 45% of the subjects successfully treated with fluoxetine continued to experience insomnia and that this “symptom” was more persistent than any of the other 9 symptoms of depression in this sample.

Comparable observations have come from CBT treatments of depression.70,71 In 2 separate randomized trials comparing CBT for depression to antidepressant medication, approximately 50% of those who remitted from depression had residual insomnia.72,73 This was also the case for a trial of CBT for posttraumatic stress disorder, in which approximately half of treatment responders had residual insomnia.74 While further studies are needed, these investigations serve to illustrate that insomnia (1) should not simply be understood as a symptom of other disorders and (2) when it occurs in the context of medical and/or psychiatric illness, may be better understood as (and treated as) a comorbid condition.

In the case of the latter question, there are now a variety of studies evaluating the efficacy of targeted insomnia treatment in patient populations with secondary insomnia. The majority of these studies have been undertaken with CBT-I. To date, there are at least 23 such investigations in both heterogeneous samples of medical or psychiatric illness and the context of specific disorders like major depression, posttraumatic stress disorder, chronic pain, fibromyalgia, and cancer.57,75-96 In general, the findings with CBT-I (assessed prospectively with sleep diaries) clearly indicate that the treatment outcomes are comparable, and in some cases superior, to those found in patients with primary insomnia. In general, the findings with CBT-I (assessed prospectively with sleep diaries) clearly indicate that the treatment outcomes are comparable, and in some cases superior, to those found in patients with primary insomnia. These findings serve as a further challenge to the relevance of the concept of secondary insomnia.

The findings with pharmacotherapy, while far fewer in number, are nicely captured by a mega-analysis recently conducted by Schaefer and colleagues.97 In this analysis, it was found that a BZRA (eszopiclone) was associated with moderate to large effects on all sleep outcomes analyzed for each of the secondary insomnias, including insomnia comorbid with MDD, generalized anxiety disorder, perimenopausal transition, and rheumatoid arthritis. The largest effects, however, were generally observed in subjects with primary insomnia. This, unlike the findings with CBT-I, serves to support the notion that the concept of secondary insomnia is relevant for treatment.

In summary, Why treat insomnia? At present, the answer is simply because insomnia can be effectively treated, and treatment can be expected to reduce insomnia-related distress and suffering in the tens of millions of patients who live with this disorder. In the future, the answer to this query is likely to be more compelling. If it can be shown that insomnia is a modifiable risk factor for medical and/or psychiatric illness and/or that targeted treatment of comorbid insomnia reliably reduces illness severity and/or promotes remission, then the answer to the question will be “because treatment for insomnia promotes better medical and/or psychiatric health.” In fact, the question “Why treat insomnia?” will, at that time, be moot, and the new questions to answer will be “When isn’ t insomnia treatment indicated?” and “Which treatment works best?” The latter of these 2 questions has been the topic of some research in the last 10 years. Unfortunately, the question has been narrowly construed as “Which treatment is better: CBT-I or pharmacotherapy with BZRAs?” On the basis of the existing studies, the simple answer to this question is that the 2 approaches yield comparable outcomes in the short term but only CBT-I has effects that persist beyond treatment discontinuation.52,98-101

The more comprehensive answer is not, at this time, possible because the more complex questions have not been addressed. For example, is it possible to produce durable effects with standard BZRAs by using alternative treatment regimens? If not, is the best use of hypnotics to promote prophylaxis in the context of acute insomnia? Is it possible that some of the types of insomnia (eg, psychophysiologic, paradoxical, idiopathic, or the pediatric insomnias) are more or less responsive to either of the current therapeutic approaches? Is it possible that some of the subtypes of insomnia (initial, middle, late, or mixed insomnia) are more or less responsive to CBT-I or pharmacotherapy? When these questions are addressed, the issues regarding the proper treatment of insomnia will have been fully explicated, and the indications for insomnia treatment will be entirely clear.

Drug names: fluoxetine (Prozac, Sarafem, and others), nortriptyline (Pamelor), zaleplon (Sonata and others), zolpidem (Ambien, Zolpimist, and others).

Disclosure of off-label usage: The authors have determined that, to the best of their knowledge, no investigational information about pharmaceutical agents that is outside US Food and Drug Administration−approved labeling has been presented in this article.

Author affiliations: Sleep and Neurophysiology Research Laboratory, Department of Psychiatry, University of Rochester, New York (Drs Matteson-Rusby and Pigeon) and Behavioral Sleep Medicine, Department of Psychiatry, University of Pennsylvania, Philadelphia (Drs Gehrman and Perlis).

Financial disclosure: Dr Perlis is a consultant for Acetelion and Takeda; has received grant/research support from Cephalon and Sanofi-Aventis; is a member of the speakers/advisory boards for Sanofi-Aventis; and has received royalties from Springer Verlag and Wiley. Dr Pigeon has received grant/research support from Merck and Sanofi-Aventis. Drs Matteson-Rusby and Gehrman have no personal affiliations or financial relationships with any commercial interest to disclose relative to the article.

Funding/support: The work related to this article was partially supported by the following National Institutes of Health grants: R01AT003332, R21MH076855, R01MH077900, R01CA126968, K23NR010408, and R21MH079187.

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