The Journal of
Clinical Psychiatry

Volume 86 • 2025 • 2

Consensus Statement

Developing a Treatment-Resistant Depression Consultation Program, Part I: Practical and Logistical Considerations

J Clin Psychiatry 2025;86(2):24cs15335

Vitaliy L. Voytenko, PsyD ; Susan K. Conroy, MD, PhD ; Anna R. Docherty, PhD ; Diana K. Burnett, MS ; Joao Quevedo, MD, PhD ; Michael J. Flood, MBA ; Patricio Riva Posse, MD ; Subhdeep Virk, MD ; Jesse H. Wright, MD, MPH ; William V. Bobo, MD, MPH ; Jay C. Fournier, PhD ; Sagar V. Parikh, MD

Consensus Statement

Developing a Treatment-Resistant Depression Consultation Program, Part II: Assessment

J Clin Psychiatry 2025;86(2):24cs15336

Jay C. Fournier, PhD ; Vitaliy L. Voytenko, PsyD ; Anna R. Docherty, PhD ; Jesse H. Wright, MD, PhD ; Subhdeep Virk, MD ; Patricio Riva Posse, MD ; Michael J. Flood, MBA ; Joao Quevedo, MD, PhD ; Diana K. Burnett, MS ; William V. Bobo, MD, MPH ; Susan K. Conroy, MD, PhD ; Sagar V. Parikh, MD

Meta-Analysis

Treating Posttraumatic Stress Disorder in Military Populations: A Meta-Analysis

J Clin Psychiatry 2025;86(2):24r15571

Jenny J. W. Liu, PhD ; Anthony Nazarov, PhD ; Natalie Ein, PhD ; Bethany Easterbrook, PhD ; Tri Le, BHSc ; Clara Baker, BA ; Julia Gervasio, MA ; Edouard Auger, MD, FRCPC ; Ken Balderson, MD, CM, FRCPC ; Mathieu Bilodeau, MD, FRCPC ; Amer M. Burhan, MBChB, MSc, FRCPC ; Murray W. Enns, MD, FRCPC ; Fardous Hosseiny, MSc ; Vicky Lavoie, PhD ; Natalie Mota, PhD ; Maya L. Roth, PhD, C.Psych ; Sonya G. Wanklyn, PhD, C.Psych ; J. Don Richardson, MD, FRCPC

Original Research

Incidence and Risk Factors for Suicide Attempt During Pregnancy and the Postpartum Period

J Clin Psychiatry 2025;86(2):24m15633

Sidra Goldman-Mellor, PhD ; Mark Olfson, MD, MPH ; Alison Gemmill, PhD ; Claire Margerison, PhD

Original Research

Improvements Over Time with Valbenazine in Elderly Adults (≥65 Years) with Tardive Dyskinesia: Post Hoc Analyses of 2 Long-Term Studies

J Clin Psychiatry 2025;86(2):24m15550

Martha Sajatovic, MD ; George S. Alexopoulos, MD ; Eric Jen, PharmD ; Khody Farahmand, PharmD ; Celia Zinger, MD

Original Research

Older Adults Visiting Emergency Departments for Mental Health Issues: A CHIRPP Database Study

J Clin Psychiatry 2025;86(2):24m15516

Maïna Laforce, MD ; Valérie Boucher, MSc ; Ann-Pier Gagnon ; Pier-Alexandre Tardif, MSc ; Axel Benhamed, MD, MSc ; Pierre-Gilles Blanchard, MD, MBA, PhD ; Marcel Emond, MD, MSc ; François Poirier, MD ; Eric Mercier, MD, MSc

Original Research

Efficacy of Adjunctive Cariprazine on Anxiety Symptoms in Patients With Major Depressive Disorder: Post Hoc Analysis of a Randomized Placebo-Controlled Trial

J Clin Psychiatry. 2025;86(2):24m15506

Maurizio Fava, MD ; Prakash S. Masand, MD ; Vladimir Maletic, MD ; Chen Chen, PhD, MS ; Julie L. Adams, MD, MPH ; Majid Kerolous, PharmD, MPH

Original Research

Vortioxetine for Cognitive Impairment in Major Depressive Disorder During Post-COVID Syndrome: Real-World Evidence

J Clin Psychiatry 2025;86(2):24m15387

Hernan F. Guillen-Burgos, MD, MSc ; Juan F. Galvez-Florez, MD ; Sergio Moreno-López, PhD ; Juan-Manuel Anaya, MD, PhD ; Angela T.H. Kwan, MSc ; Roger S. McIntyre, MD, FRCPC

Original Research

Prevalence and Association of Defense Mechanisms With Common Psychiatric Disorders: A National Study

J Clin Psychiatry 2025;86(2):24m15582

Carlos Blanco, MD, PhD ; Leonie Kampe, PhD ; Melanie M. Wall, PhD ; Shuai Wang, PhD ; Eve Caligor, MD ; Mark Olfson, MD, MPH

Original Research

Public Health Nurse–Delivered 1-Day Cognitive Behavioral Therapy–Based Workshops for Treating Postpartum Depression: A Pilot Randomized Controlled Trial

J Clin Psychiatry 2025;86(2):24m15712

Haley Layton, MPH ; Madisyn Campbell, BA ; Kathryn Huh, BHSc ; Arooba Mansoor, HBSc ; Jesus Serrano-Lomelin, PhD ; June S. L. Brown, PhD ; Peter J. Bieling, PhD ; Ryan J. Van Lieshout, MD, PhD

Original Research

Increased Risk of Suicide Attempt in Patients With Atopic Dermatitis: A Nationwide Population-Based Cohort Study

J Clin Psychiatry 2025;86(2):24m15590

Mu-Chun Lin, MD ; Sheng-Hsiang Ma, MD ; Ying-Hsuan Tai, MD ; Ying-Xiu Dai, MD ; Mu-Hong Chen, MD, PhD ; Chih-Chiang Chen, MD, PhD

Original Research

Antidepressant Medication Prescription and Incident Cardiovascular Disease in Women Veterans

J Clin Psychiatry 2025;86(2):24m15647

Jennifer A. Sumner, PhD ; Paul A. Dennis, PhD, MSA ; Carlos A. Alvarez, PharmD ; Aaron Perkins, MS ; Jean C. Beckham, PhD ; Ramin Ebrahimi, MD

Original Research

One-Day Online Cognitive Behavioral Therapy–Based Workshops for the Prevention of Postpartum Depression: A Randomized Controlled Trial

J Clin Psychiatry 2025;86(2):24m15674

Zoe Boland, MSc ; Nancy Lloyd, MSc ; Jaslyn Drage, BSc ; Jesus Serrano-Lomelin, PhD ; Peter Bieling, PhD ; David Streiner, PhD ; Ryan J. Van Lieshout, PhD, MD

Original Research

Preferences for Lisdexamfetamine vs Cognitive-Behavioral Therapy for Binge-Eating Disorder: Correlates and Outcomes

J Clin Psychiatry 2025;86(2):24m15552

Sydney Yurkow, PhD ; Valentina Ivezaj, PhD ; Brian Pittman, MS ; Carlos M. Grilo, PhD

Original Research

Results of a Randomized Controlled Trial Examining the Efficacy of Intranasal Oxytocin to Enhance Alcohol Behavioral Couple Therapy

J Clin Psychiatry 2025;86(2):24m15627

Julianne C. Flanagan, PhD ; Paul J. Nietert, PhD ; Barbara S. McCrady, PhD ; Stacey Sellers, MS ; Anjinetta Yates-Johnson, PA ; Sarah T. Giff, PhD ; Shannon R. Forkus, PhD

Original Research

Is Posttraumatic Stress Disorder in a Class of Its Own? Longitudinal Comparison to Other Conditions Following Trauma and Life Stress Exposure

J Clin Psychiatry 2025;86(2):24m15591

Ashley L. Greene, PhD ; Holly F. Levin-Aspenson, PhD ; Scott Feltman, MA ; Stephen Long, PhD ; Madeleine Moore, BS ; Camilo Ruggero, PhD ; Sean A. P. Clouston, PhD ; Evelyn J. Bromet, PhD ; Benjamin J. Luft, MD ; Roman Kotov, PhD

Original Research

Evidence-Based and Evidence-Informed Treatments: A Naturalistic Study of the Impact of Treatment Type on Engagement in Posttraumatic Stress Disorder

J Clin Psychiatry 2025;86(2):24m15567

Melanie Arenson, PhD ; Baylee Crone, PhD ; Ranon Cortell, PhD ; Elisabeth Carlin, PhD

Original Research

Delirium as a Precursor to Dementia in Elderly Type 2 Diabetes Mellitus Patients

J Clin Psychiatry 2025;86(2):25m15798

Mingyang Sun, MD ; Xiaoling Wang, PhD ; Zhongyuan Lu, PhD ; Yitian Yang, MD, PhD ; Shuang Lv, MD ; Mengrong Miao, MD ; Wan-Ming Chen, PhD ; Szu-Yuan Wu, MD, MPH, PhD ; Jiaqiang Zhang, MD, PhD

Original Research

Suicide Among Veterans Health Administration Patients With Bipolar Disorder: Evidence for Increased Risk Associated With Benzodiazepine Receipt

J Clin Psychiatry 2025;86(2):24m15424

Kevin G. Saulnier, PhD ; Anna L. Philibert, MPH ; Peter P. Grau, PhD ; Nicholas W. Bowersox, PhD

Original Research

Longitudinal Effects of Negative Ethnic-Racial Identity Affect on Internalizing Symptoms in Youth of Latiné Background Exposed to Interpersonal Trauma

J Clin Psychiatry 2025;86(2):24m15654

Sunita M. Stewart, PhD ; Nazan Aksan, PhD ; Andrea Bancroft, BS ; Jeffrey D. Shahidullah, PhD ; Savannah M. Krantz, BA ; Madelyn Guerra, MS ; Jessica Sandoval, MD ; Cynthia Garza, PsyD ; Andres G. Viana, PhD ; Myesha Morgan, PhD ; Cecilia DeVargas, MD ; Justin F. Rousseau, MD ; D. Jeffrey Newport, MD ; Karen Dineen Wagner, MD, PhD ; Charles B. Nemeroff, MD, PhD

Original Research

Xanomeline and Trospium Chloride for the Treatment of Agitation Associated With Schizophrenia: PANSS-Excited Component Results From 3 Randomized, Double-Blind, Placebo-Controlled EMERGENT Trials

J Clin Psychiatry 2025;86(2):24m15668

Paul P. Yeung, MD, MPH ; Alan Breier, MD ; Haiyuan Zhu, PhD ; Inder Kaul, MD, MPH ; Ronald N. Marcus, MD

Original Research

A Single-Dose, Randomized, Open-Label, Parallel Design Study to Characterize the Pharmacokinetics of an Investigational Olanzapine Intranasal Spray Compared to a Reference Dose of Olanzapine Intramuscular Injection in Healthy Adult Males

J Clin Psychiatry 2025;86(2):24m15665

Stuart Madden, PhD ; Leslie Citrome, MD, MPH ; Christoph U. Correll, MD, PhD ; Evelyn K. Shih, MD, PhD ; Miguel Lopez-Toledano, PhD ; Adrian L. Rabinowicz, MD ; Enrique Carrazana, MD

Original Research

Effects of Parental Severe Mental Disorders on All-Cause and Suicide Mortalities in Adolescents and Young Adults With Major Depressive Disorder

J Clin Psychiatry 2025;86(2):24m15476

Shih-Jen Tsai, MD ; Chih-Ming Cheng, MD ; Wen-Han Chang, MS ; Ya-Mei Bai, MD, PhD ; Tung-Ping Su, MD ; Tzeng-Ji Chen, MD, PhD ; Mu-Hong Chen, MD, PhD

Original Research

Combining Ketamine Infusions and Written Exposure Therapy for Chronic PTSD: An Open-Label Trial

J Clin Psychiatry 2025;86(2):24m15622

Adriana Feder, MD ; Oneysha Brown, BA ; Sarah B. Rutter, MA ; Leah Cahn, LCSW ; Jessica R. Overbey, DrPH ; Saren H. Seeley, PhD ; Alex Yu, MD ; Philip A. Bonanno, MD ; Rachel A. Fremont, MD, PhD ; Andrew A. Delgado, PhD ; Manish K. Jha, MD ; Sara Costi, MD ; Rachel Yehuda, PhD ; Daniela Schiller, PhD ; Robert H. Pietrzak, PhD, MPH ; Dennis S. Charney, MD ; Denise M. Sloan, PhD ; James W. Murrough, MD, PhD

Original Research

Trajectories of Irritability Improvement in Depressed Adolescents Treated With 1 Hz and 10 Hz Transcranial Magnetic Stimulation

J Clin Psychiatry 2025;86(2):24m15684

Karina Delaney, BS ; Paul A. Nakonezny, PhD ; Dicle Buyuktaskin, MD ; Lucero Sangster Carrasco, MD ; Arjun P. Athreya, MS, PhD ; Magdalena Romanowicz, MD ; Julia Shekunov, MD ; Jennifer L. Vande Voort, MD ; Paul E. Croarkin, DO, MS

Original Research

Appetite Hormone Regulation Biotypes of Major Affective Disorders in Proinflammatory Cytokines and Executive Function

J Clin Psychiatry 2025;86(2):24m15561

Ju-Wei Hsu, MD ; Wei-Chen Lin, MD, PhD ; Ya-Mei Bai, MD, PhD ; Shih-Jen Tsai, MD ; Mu-Hong Chen, MD, PhD

Academic Highlights

Optimizing Treatment With Aripiprazole Monohydrate: Pharmacokinetic Advantages of Long-Acting Injectable Formulations, A Consensus Panel Report

J Clin Psychiatry 2025;86(2):plunlai2424ah1

Joseph F. Goldberg, MD ; Eric D. Achtyes, MD, MS ; Christoph U. Correll, MD ; Martha Sajatovic, MD ; Stephen R. Saklad, PharmD, BCPP

Commentary

Benefits and Risks of New Tests for Alzheimer’s Disease

J Clin Psychiatry 2025;86(2):25com15837

Gary W. Small, MD ; Maxwell Z. Price, BA

Commentary

Lower Risk of First Onset of Many Cardiovascular Disorders in Antidepressant-Treated Women Veterans: Encouraging Findings but Concerns Remain

J Clin Psychiatry 2025;86(2):25com15886

Chittaranjan Andrade, MD

Commentary

Back to the Office: The Room Where It Happens?

J Clin Psychiatry 2025;86(2):24com15710

John C. Markowitz, MD ; Barbara Milrod, MD ; Timothy G. Heckman, PhD ; Maja Bergman, PhD ; Doron Amsalem, MD ; Yuval Neria, PhD

Commentary

Eating Disorders Among Transgender and Gender Diverse People: A Qualitative Analysis of Reddit Threads

J Clin Psychiatry 2025;86(2):24com15640

Sofia E. Guerra ; Nora Y. Sun ; Alex S. Keuroghlian, MD, MPH

Commentary

Investigation of Appetite Hormones and Their Association With Mood Disorders Illustrates the Current Limitations of Psychiatric Diagnosis

J Clin Psychiatry 2025;86(2):25com15802

David Mischoulon, MD, PhD

Clinical and Practical Psychopharmacology

Autism Spectrum Disorder, 2: Observations on the Imprecision of the Numerical Value of Risk when Examining Predictors of Risk in Regression

J Clin Psychiatry 2025;86(2):25f15918

Chittaranjan Andrade, MD

Clinical and Practical Psychopharmacology

Discordant Sibling Pair Comparisons in Observational Studies: A Research Design Simply Explained

J Clin Psychiatry 2025;86(2):25f15843

Chittaranjan Andrade, MD

Clinical and Practical Psychopharmacology

Autism Spectrum Disorder, 1: Genetic and Environmental Risk Factors

J Clin Psychiatry 2025;86(2):25f15878

Chittaranjan Andrade, MD

ASCP Corner

Clozapine Monitoring in the Post-REMS World: Some Guidance for Clinicians

J Clin Psychiatry 2025;86(2):25ac15898

Jonathan M. Meyer, MD ; Jose M. Rubio, MD, PhD

Brief Report

Psychosocial Correlates of Optimism Among US Military Veterans

J Clin Psychiatry 2025;86(2):25br15791

Rick Yang, HSD ; Ian C. Fischer, PhD ; Peter J. Na, MD, MPH ; Robert H. Pietrzak, PhD, MPH

Brief Report

The Association Between Infant Distress to Limitation and Postpartum Depression Treatment Response

J Clin Psychiatry 2025;86(2):24br15503

Kian Yousefi Kousha, MSc ; John E. Krzeczkowski, PhD ; Ryan J. Van Lieshout, MD, PhD

Case Report

A Case of Semaglutide-Induced Euphoria in a Patient With Bipolar Disorder

J Clin Psychiatry 2025;86(1):25cr15778

Norman R. Greenberg, MD ; Florence Yu, MD ; Richard A. Friedman, MD

Letter to the Editor

Erecting Barriers to Suicide by Removing Barriers to Science

J Clin Psychiatry 2025;86(2):25l15883

Gin S. Malhi, MBChB, BSc (Hons), MSt, MD ; Kinga Szymaniak, PsyM, PhD ; Gurubhaskar Shivakumar, MBBS, MP ; Erica Bell, BSc

Letter to the Editor

The Need for Guidance on Ketamine/Esketamine Use in Real-World Clinical Settings

J Clin Psychiatry 2025;86(2):24lr15709

Alina Wilkowska, MD, PhD ; Wiesław Jerzy Cubała, MD, PhD

Correction

Correction. Long-Term Safety and Efficacy of Esmethadone in Patients With Major Depressive Disorder: Findings From a 12-Month Open-Label Study

J Clin Psychiatry 2025;86(2):25lcx15938

Volume 86 • 2025 • 2

Consensus Statement

Developing a Treatment-Resistant Depression Consultation Program, Part I: Practical and Logistical Considerations

Developing a Treatment-Resistant Depression Consultation Program, Part II: Assessment

Meta-Analysis

Treating Posttraumatic Stress Disorder in Military Populations: A Meta-Analysis

Original Research

Incidence and Risk Factors for Suicide Attempt During Pregnancy and the Postpartum Period

Improvements Over Time with Valbenazine in Elderly Adults (≥65 Years) with Tardive Dyskinesia: Post Hoc Analyses of 2 Long-Term Studies

Older Adults Visiting Emergency Departments for Mental Health Issues: A CHIRPP Database Study

Efficacy of Adjunctive Cariprazine on Anxiety Symptoms in Patients With Major Depressive Disorder: Post Hoc Analysis of a Randomized Placebo-Controlled Trial

Vortioxetine for Cognitive Impairment in Major Depressive Disorder During Post-COVID Syndrome: Real-World Evidence

Prevalence and Association of Defense Mechanisms With Common Psychiatric Disorders: A National Study

Public Health Nurse–Delivered 1-Day Cognitive Behavioral Therapy–Based Workshops for Treating Postpartum Depression: A Pilot Randomized Controlled Trial

Increased Risk of Suicide Attempt in Patients With Atopic Dermatitis: A Nationwide Population-Based Cohort Study

Antidepressant Medication Prescription and Incident Cardiovascular Disease in Women Veterans

One-Day Online Cognitive Behavioral Therapy–Based Workshops for the Prevention of Postpartum Depression: A Randomized Controlled Trial

Preferences for Lisdexamfetamine vs Cognitive-Behavioral Therapy for Binge-Eating Disorder: Correlates and Outcomes

Results of a Randomized Controlled Trial Examining the Efficacy of Intranasal Oxytocin to Enhance Alcohol Behavioral Couple Therapy

Is Posttraumatic Stress Disorder in a Class of Its Own? Longitudinal Comparison to Other Conditions Following Trauma and Life Stress Exposure

Evidence-Based and Evidence-Informed Treatments: A Naturalistic Study of the Impact of Treatment Type on Engagement in Posttraumatic Stress Disorder

Delirium as a Precursor to Dementia in Elderly Type 2 Diabetes Mellitus Patients

Suicide Among Veterans Health Administration Patients With Bipolar Disorder: Evidence for Increased Risk Associated With Benzodiazepine Receipt

Longitudinal Effects of Negative Ethnic-Racial Identity Affect on Internalizing Symptoms in Youth of Latiné Background Exposed to Interpersonal Trauma

Xanomeline and Trospium Chloride for the Treatment of Agitation Associated With Schizophrenia: PANSS-Excited Component Results From 3 Randomized, Double-Blind, Placebo-Controlled EMERGENT Trials

A Single-Dose, Randomized, Open-Label, Parallel Design Study to Characterize the Pharmacokinetics of an Investigational Olanzapine Intranasal Spray Compared to a Reference Dose of Olanzapine Intramuscular Injection in Healthy Adult Males

Effects of Parental Severe Mental Disorders on All-Cause and Suicide Mortalities in Adolescents and Young Adults With Major Depressive Disorder

Combining Ketamine Infusions and Written Exposure Therapy for Chronic PTSD: An Open-Label Trial

Trajectories of Irritability Improvement in Depressed Adolescents Treated With 1 Hz and 10 Hz Transcranial Magnetic Stimulation

Appetite Hormone Regulation Biotypes of Major Affective Disorders in Proinflammatory Cytokines and Executive Function

Academic Highlights

Optimizing Treatment With Aripiprazole Monohydrate: Pharmacokinetic Advantages of Long-Acting Injectable Formulations, A Consensus Panel Report

Commentary

Benefits and Risks of New Tests for Alzheimer’s Disease

Lower Risk of First Onset of Many Cardiovascular Disorders in Antidepressant-Treated Women Veterans: Encouraging Findings but Concerns Remain

Back to the Office: The Room Where It Happens?

Eating Disorders Among Transgender and Gender Diverse People: A Qualitative Analysis of Reddit Threads

Investigation of Appetite Hormones and Their Association With Mood Disorders Illustrates the Current Limitations of Psychiatric Diagnosis

Clinical and Practical Psychopharmacology

Autism Spectrum Disorder, 2: Observations on the Imprecision of the Numerical Value of Risk when Examining Predictors of Risk in Regression

Discordant Sibling Pair Comparisons in Observational Studies: A Research Design Simply Explained

Autism Spectrum Disorder, 1: Genetic and Environmental Risk Factors

ASCP Corner

Clozapine Monitoring in the Post-REMS World: Some Guidance for Clinicians

Brief Report

Psychosocial Correlates of Optimism Among US Military Veterans

The Association Between Infant Distress to Limitation and Postpartum Depression Treatment Response

Case Report

A Case of Semaglutide-Induced Euphoria in a Patient With Bipolar Disorder

Letter to the Editor

Erecting Barriers to Suicide by Removing Barriers to Science

The Need for Guidance on Ketamine/Esketamine Use in Real-World Clinical Settings

Correction

Correction. Long-Term Safety and Efficacy of Esmethadone in Patients With Major Depressive Disorder: Findings From a 12-Month Open-Label Study

Watch the New PsychCase360

Subscribe to readmore articles

Subscribe to read
more articles