The Journal of
Clinical Psychiatry

Volume 86 • 2025 • 3

In Memoriam

In Memoriam: Terence A. Ketter, MD

J Clin Psychiatry 2025;86(3):25f16060

Alan F. Schatzberg, MD; Robert Post, MD

Narrative Review

Idiopathic Hypersomnia: Recognition and Management in Psychiatric Practice

J Clin Psychiatry 2025;86(3):24nr15718

Craig Chepke, MD, DFAPA; Ruth M. Benca, MD, PhD; Andrew J. Cutler, MD; Andrew D. Krystal, MD; Nathaniel F. Watson, MD, MSc

Original Research

Rapid Onset and Sustained Efficacy of Onfasprodil (MIJ821), a Novel NR2B Negative Allosteric Modulator, in Patients With Treatment-Resistant Depression: A Phase 2, Randomized, Placebo-Controlled, Proof-of-Concept Study

J Clin Psychiatry 2025;86(3):23m15246

Richard C. Shelton, MD; Robert E. Litman, MD; Howard Hassman, DO; David P. Walling, PhD; Salvador Ros Montalbán, MD; Joan Salvà-Coll, MD; John Zajecka, MD; Oleksandr Sverdlov, PhD; Baltazar Gomez-Mancilla, MD, PhD; Mark P. Healy, PhD; Y. Gopi Shanker, PhD; Maria Berkheimer, PhD; Thomas Faller, PhD; Florian von Raison, MD; Carmen Serban, MD; Jang-Ho Cha, MD, PhD; S. Nassir Ghaemi, MD, MPH

Original Research

Klotho and Matrix Metalloproteinase-9 Levels and Their Association With Inhibitory Dyscontrol in Adolescents With First-Episode Major Affective Disorders

J Clin Psychiatry 2025;86(3):24m15696

Li-Chi Chen, MD; Ya-Mei Bai, MD, PhD; Shih-Jen Tsai, MD; Ju-Wei Hsu, MD; Mu-Hong Chen, MD, PhD

Original Research

Efficiency and Extent of Niacin-Induced Skin Flushing Patterns in Early Stages of Psychosis

J Clin Psychiatry 2025;86(3):24m15559

TianHong Zhang, PhD; LiHua Xu, PhD; YanYan Wei, PhD; XiaoChen Tang, PhD; RanPiao Gan, MD; Dan Zhang, PhD; ZhengHui Yi, PhD; XiaoHua Liu, PhD; HaiChun Liu, PhD; ZiXuan Wang, MD; Tao Chen, PhD; Jin Gao, PhD; Qiang Hu, PhD; LingYun Zeng, PhD; ChunBo Li, PhD; JiJun Wang, PhD

Original Research

Early Response to Ketamine for Suicidal Crisis Reduces Suicidal Events at 3 Months

J Clin Psychiatry 2025;86(3):25m15829

Martin Pastre, MD, Msc; Raphael Chancel, MD; Manon Malestroit, PhD; Philippe Courtet, MD, PhD; Emilie Olié, MD, PhD

Original Research

Effect of Nature Videos on the Burden of Caregivers of Patients With Dementia

J Clin Psychiatry 2025;86(3):25m15817

Kritta Supanimitamorn, MD, FRCPsychT; Gobhathai Sittironnarit, MD, FRCPsychT; Kankamol Jaisin, MD, MSc, FRCPsychT; Naratip Sa-nguanpanich, BSc; Kitikan Thana-udom, MD, FRCPsychT

$Long-Term Outcomes in Patients With Treatment-Refractory Depression Receiving Intravenous Ketamine and Intranasal Esketamine: An Observational Study$

Original Research

Long-Term Outcomes in Patients With Treatment-Refractory Depression Receiving Intravenous Ketamine and Intranasal Esketamine: An Observational Study

J Clin Psychiatry 2025;86(3):25m15831

Balwinder Singh, MD, MS; Vanessa K. Pazdernik, MS; Simon Kung, MD; Jennifer L. Vande Voort, MD

Original Research

Early Change in Depressive Symptom Severity With Naltrexone-Bupropion Combination and Its Association With Reduction in Methamphetamine Use in ADAPT-2 Trial

J Clin Psychiatry 2025;86(3):25m15825.

Manish K. Jha, MBBS; Udi E. Ghitza, PhD; Steve Shoptaw, PhD; Abu Minhajuddin, PhD; Snoben Kuruvila, MPAS; Sidarth Wakhlu, MD; Edward V. Nunes, MD; Joy Schmitz, PhD; Phillip O. Coffin, MD; Gavin Bart, MD, PhD; Thomas Carmody, PhD; Madhukar H. Trivedi, MD

Original Research

Artificial Intelligence in Depression–Medication Enhancement (AID-ME): A Cluster Randomized Trial of a Deep-Learning-Enabled Clinical Decision Support System for Personalized Depression Treatment Selection and Management

J Clin Psychiatry 2025;86(3):24m15634

David Benrimoh, MD, CM, MSc, FRCPC; Kate Whitmore, MSc; Maud Richard, MSc, RAC; Grace Golden, MSc; Kelly Perlman, PhD; Sara Jalali, MSc; Timothy Friesen, MSc; Youcef Barkat, MSc, MSc; Joseph Mehltretter, MSc; Robert Fratila; Caitrin Armstrong, MSc; Sonia Israel; Christina Popescu, MSc; Jordan F. Karp, MD; Sagar V. Parikh, MD, FRCPC; Shirin Golchi, MSc, PhD; Erica E. M. Moodie, MPhil, MSc, PhD; Junwei Shen, MSc, PhD; Anthony J. Gifuni, MD, MSc, FRCPC; Manuela Ferrari, PhD; Mamta Sapra, MD; Stefan Kloiber, MD; Georges-F. Pinard, MD, FRCPC; Boadie W. Dunlop, MSc, MD; Karl Looper, MD, MSc; Mohini Ranganathan, MD; Martin Enault; Serge Beaulieu, MD, PhD, FRCPC; Soham Rej, MD, MSc, FRCPC; Fanny Hersson-Edery, MD; Warren Steiner, MD, FRCPC, FAPA; Alexandra Anacleto; Sabrina Qassim; Rebecca McGuire-Snieckus, MSc, PhD, FRSS; Howard C. Margolese, MSc, MD, CM, FRCPC

Original Research

Prognostic and Prescriptive Predictors of Treatment Response to Adjunctive VNS Therapy in Major Depressive Disorder: A RECOVER Trial Report

J Clin Psychiatry 2025;86(3):25m15850

Scott T. Aaronson, MD; Charles R. Conway, MD; Charles Gordon, MS; Ying-Chieh (Lisa) Lee, MS; Mark S. George, MD; John Zajecka, MD; Patricio Riva-Posse, MD; David L. Dunner, MD; Matthew Macaluso, MD; Peter B. Rosenquist, MD; Brian J. Mickey, MD; Yvette I. Sheline, MD; Vasilis C. Hristidis, MD; Hunter Brown, MSW; Christopher L. Kriedt, BSN; Quyen Tran, BS, MBA; Mark T. Bunker, PharmD; Harold A. Sackeim, PhD; A. John Rush, MD

Original Research

Delineating the Effects of Alcohol Use on Cognition in Individuals With Neurocognitive Disorders

J Clin Psychiatry 2025;86(3): 24m15738

Ari B. Cuperfain, MD; Sandra E. Black, MD; Mira Fostoc, BSc; Morris Freedman, MD; Clement Ma, PhD; Tarek Rajji, MD; Stephen Strother, PhD; David F. Tang-Wai, MD; Maria Carmela Tartaglia, MD; Sanjeev Kumar, MD; TDRA Clinical Research Database Group

Original Research

Treatment Use and Preference in a Diverse Sample of Women With Mood Disorders

J Clin Psychiatry 2025; 86(3):25m15823

Robert T. Ammerman, PhD; Megan E. Deichen Hansen, MSW, PhD; Rhonda C. Boyd, PhD; Kayla D. Longoria, PhD, RN; Melissa Wagner-Schuman, MD, PhD; Diana I. Simeonova, PhD, Dipl-Psych; Heather A. Flynn, PhD; Sandra J. Weiss, PhD, DNSc

Original Research

Understanding the Characteristics and Burden of Cognitive Impairments in Schizophrenia in the US: Medical Expenditure Panel Survey

J Clin Psychiatry 2025;86(3):25m15794

Briana M. Choi, PharmD, PhD; Tavneet Singh, PhD; Mona Nili, PharmD, PhD; Cindy Lam, MPH; Pin Xiang, PharmD, MS; November McGarvey, PhD, MPH; Christoph U. Correll, MD

Original Research

Comparative Effectiveness Research Trial for Antidepressant Incomplete and Nonresponders With Treatment Resistant Depression (ASCERTAIN-TRD): Effect of Aripiprazole or Repetitive Transcranial Magnetic Stimulation Augmentation Versus Switching to the Antidepressant Venlafaxine on Quality of Life

J Clin Psychiatry 2025;86(3):24m15614

Original Research

Levomilnacipran, but Not Duloxetine, Inhibits Serotonin and Norepinephrine Reuptake Throughout Its Therapeutic Range

J Clin Psychiatry 2025;86(3):25m15867

Katerina Nikolitch, MD, MSc; Jennifer L. Phillips, PhD; Stephen Daniels, PhD; Pierre Blier, MD, PhD

Original Research

Prediction of Adolescent Suicidal Events by Residual Depressive Symptoms After Intensive Treatment

J Clin Psychiatry 2025;86(3):24m15462

Graham J. Emslie, MD; Sunita M. Stewart, PhD; Muruga A. Loganathan, MD; Stephen Buerkert, BS; Gabriela Lange Valenga, BS

Original Research

Outpatient Ketamine Prescribing Practices in Psychiatry in the United States: A Nationwide Survey Study

J Clin Psychiatry 2025;86(3):25m15809

Sagar V. Parikh, MD; Rachel M. Pacilio, MD; Jamarie Geller, MD, MA

Original Research

Detecting Tardive Dyskinesia Using Video-Based Artificial Intelligence

J Clin Psychiatry 2025;86(3):25m15792

Joseph H. Friedman, MD; Anthony A. Sterns, PhD; Joel W. Hughes, PhD; Bradley Grimm, MS; Loren Larsen, MS; Fred Ma, MD, PhD; Rakesh Ranjan, MD; Carlene MacMillan, MD; Bretton H. Talbot, PhD; Owen S. Muir, MD

Original Research

Cognitive Behavioral Therapy for Insomnia With Prolonged Exposure Compared to Sleep Hygiene and Prolonged Exposure: A Randomized Controlled Trial

J Clin Psychiatry 2025;86(3):24m15584

Peter J. Colvonen, PhD; Christopher Hunt, PhD; Jane Park, BS; Abigail C. Angkaw, PhD; Philip Gehrman, PhD; Kira Clare, BS; Sonya B. Norman, PhD

Original Research

Risk of Alzheimer Disease and Vascular Dementia in Patients With Peripheral Vestibular Disorders: A Longitudinal Study of 140,726 Participants

J Clin Psychiatry 2025;86(3):24m15699

Yun-Hsuan Lin, BS; Mu-Hong Chen, MD, PhD; Shun-Chieh Yu, MD; Ya-Mei Bai, MD, PhD; Tung-Ping Su, MD; Tzeng-Ji Chen, MD, PhD; Shih-Jen Tsai, MD

Original Research

Association Between Adult Sexual Assault and Psychiatric Disorders: Results From the National Epidemiologic Survey on Alcohol and Related Conditions-III

J Clin Psychiatry 2025;86(3):24m15631

Yann Le Strat, MD, PhD; Caroline Dubertret, MD, PhD; Sarah Tebeka, MD, PhD; Domitille Tisseau, MD; Elodie-Gaëlle Ngameni, MD, PhD

Original Research

Postpartum Distress Among Women With and Without Attention-Deficit/Hyperactivity Disorder

J Clin Psychiatry 2025;86(3):24m15724

Dara E. Babinski, PhD; Kirsten Riggle, MPH; Wen-Jan Tuan, PhD

Original Research

Bright Light Therapy in the Morning or Midday for the Treatment of Nonseasonal Depression in Bipolar Disorder (LuBi): A Dose-Escalation Phase 1/2 Randomized Double-Blind Trial

J Clin Psychiatry 2025;86(3):25m15826

Pierre A. Geoffroy, MD, PhD; Sylvie Chevret, MD, PhD; Sibylle Mauries, MD; Cendrine Chaffaut, MSc; Ali Amad, MD, PhD; Frank Bellivier, MD, PhD; Victoire Benard, MD, PhD; Philippe Courtet, MD, PhD; Caroline Dubertret, MD, PhD; Philip Gorwood, MD, PhD; Nicolas Mazer, MD; Lila Mekaoui, MD; Emilie Olié, MD, PhD; Guillaume Pataud, MD; Guillaume Vaiva, MD, PhD; Michel Lejoyeux, MD, PhD; Dorothy Sit, MD, PhD; Julia Maruani, MD, MSc

Original Research

Differentiating Subtypes of Major Depressive Disorder Using Serum Biomarkers

J Clin Psychiatry 2025;86(3):25m15828

Jae-Min Kim, MD, PhD; Hee-Ju Kang, MD, PhD; Ju-Yeon Lee, MD, PhD; Ju-Wan Kim, MD, MSc; Honey Kim, MD, MSc; Min Jhon, MD, MSc; Sung-Wan Kim, MD, PhD; Il-Seon Shin, MD, PhD

Original Research

Using GenAI to Train Mental Health Professionals in Suicide Risk Assessment: Preliminary Findings

J Clin Psychiatry 2025;86(3):24m15525

Zohar Elyoseph, PhD; Inbar Levkovitch, PhD; Yuval Haber, MA; Yossi Levi-Belz, PhD

Original Research

A Global Population-Based Study on the Association Between Ketamine and Esketamine With Suicidality Using WHO VigiBase

J Clin Psychiatry 2025;86(3):24m15534

Angela T.H. Kwan, MD(C), MSc; Moiz Lakhani, MD(C), BHSc; Joshua D. Rosenblat, MD, MSc, FRCPC; Rodrigo B. Mansur, MD, PhD; Taeho Greg Rhee, PhD; Kayla M. Teopiz, HBSc; Bing Cao, PhD; Roger Ho, MD, FRCPsych; Sabrina Wong, HBSc; Gia Han Le, HBSc; Roger S. McIntyre, MD, FRCPC

Original Research

A Case Series of Intimate Partner Violence in Older Adults Within an Older Persons’ Mental Health Service

J Clin Psychiatry 2025; 86(3):24m15495

Anant Sharma, BMedSc, MBBS, MMed (Psych); Sharon Reutens, MBBS, PhD, FRANZCP; Anne P. F. Wand, MBBS, PhD, FRANZCP

Original Research

Exploring Vascular Endothelial Growth Factor and Other Blood-Brain Barrier Biomarkers in Cognition of First-Episode Psychosis: An Observational Study

J Clin Psychiatry 2025;86(3):24m15486

Alejandro Ballesteros, MD; María Flores-Lopez, MSc; Ana M. Sánchez-Torres, PhD; Gustavo J. Gil-Berrozpe, MSc; Lucía Moreno-Izco, MSc; Ana Gavito, MSc; Antonia Serrano, MSc; Fernando Rodríguez de Fonseca, MD, PhD; Manuel J. Cuesta, MD, PhD

Original Research

Actigraphy-Measured Sleep/Wake Characteristics Associated With Suicidal Ideation in Older Adults Who Have Depression and High Suicide Risk

J Clin Psychiatry 2025;86(3):24m15522

Stephen F. Smagula, PhD; Gehui Zhang, PhD; Sara Albert, MS; Sarah Lim, MD; Allison G. Harvey, PhD; Michael R. Irwin, MD; William Vaughn McCall, MD; Charles F. Reynolds III, MD; Daniel J. Buysse, MD; Robert T. Krafty, PhD

Academic Highlights

Clinical Application of Aripiprazole Monohydrate Long-Acting Injectables for the Treatment of Bipolar Type I Disorder: A Consensus Panel Report

J Clin Psychiatry 2025;86(3):plunlai2424ah3

Joseph F. Goldberg, MD; Eric D. Achtyes, MD, MS; Martha Sajatovic, MD; Stephen R. Saklad, PharmD, BCPP; Christoph U. Correll, MD

Academic Highlights

Clinical Application of Aripiprazole Monohydrate Long-Acting Injectables for the Treatment of Schizophrenia: A Consensus Panel Report

J Clin Psychiatry 2025;86(3):plunlai2424ah2

Christoph U. Correll, MD; Eric D. Achtyes, MD, MS; Martha Sajatovic, MD; Stephen R. Saklad, PharmD, BCPP; Joseph F. Goldberg, MD

Commentary

How Do We Get Ketamine Safety Right? Three Questions From a Clinical Service

J Clin Psychiatry 2025;86(3):25com15946

Benjamin D. Brody, MD; Dennis M. Popeo, MD, MSc; Roy W. Smetana, MD, PhD; Dora Kanellopoulos, PhD

Clinical and Practical Psychopharmacology

The Superiority of Clozapine Over Second-Generation Antipsychotics in Patients With Treatment-Resistant Schizophrenia: Room for Doubt

J Clin Psychiatry 2025;86(3):25f16038

Chittaranjan Andrade, MD

Clinical and Practical Psychopharmacology

Schizophrenia, Antipsychotic Drugs, and Risk of Breast Cancer

J Clin Psychiatry 2025;86(3):25f15960

Chittaranjan Andrade, MD

Clinical and Practical Psychopharmacology

A Primer on Individual Participant Data Meta-Analysis and Its Strengths and Limitations

J Clin Psychiatry 2025;86(3):25f16001

Chittaranjan Andrade, MD

ASCP Corner

What Clinicians Should Know About the Pragmatic Use of Xanomeline-Trospium Combination

J Clin Psychiatry 2025;86(3):25ac15945

Joseph F. Goldberg, MD; Peter J. Weiden, MD

Case Report

Worth the Weight? The Challenges of Administering the Glucagon-Like Peptide 1 Receptor Agonist Semaglutide With Long-Term Olanzapine Use in a Patient With Schizophrenia

J Clin Psychiatry 2025;86(3):25cr15857

Francesca L. Ricciardi, MA; Jayda L. Melnitsky, BA; Shannon B. Peleg, BA; Preetika Govil, BS; Joshua T. Kantrowitz, MD

Case Report

Zuranolone for Postpartum Depression in Real-World Clinical Practice

J Clin Psychiatry 2025;86(3):25cr15876

Maxwell Z. Price, BA; Richard L. Price, MD

Letter to the Editor

Suicide Risk Among Patients with Bipolar Disorder: The Role of Sleep Disruption Versus Benzodiazepine Use

J Clin Psychiatry 2025;86(3):25lr15890.

Andrew S. Tubbs, MD, PhD; Fabian-Xosé Fernandez, PhD

Volume 86 • 2025 • 3

In Memoriam

In Memoriam: Terence A. Ketter, MD

Narrative Review

Idiopathic Hypersomnia: Recognition and Management in Psychiatric Practice

Original Research

Rapid Onset and Sustained Efficacy of Onfasprodil (MIJ821), a Novel NR2B Negative Allosteric Modulator, in Patients With Treatment-Resistant Depression: A Phase 2, Randomized, Placebo-Controlled, Proof-of-Concept Study

Klotho and Matrix Metalloproteinase-9 Levels and Their Association With Inhibitory Dyscontrol in Adolescents With First-Episode Major Affective Disorders

Efficiency and Extent of Niacin-Induced Skin Flushing Patterns in Early Stages of Psychosis

Early Response to Ketamine for Suicidal Crisis Reduces Suicidal Events at 3 Months

Effect of Nature Videos on the Burden of Caregivers of Patients With Dementia

Long-Term Outcomes in Patients With Treatment-Refractory Depression Receiving Intravenous Ketamine and Intranasal Esketamine: An Observational Study

Early Change in Depressive Symptom Severity With Naltrexone-Bupropion Combination and Its Association With Reduction in Methamphetamine Use in ADAPT-2 Trial

Artificial Intelligence in Depression–Medication Enhancement (AID-ME): A Cluster Randomized Trial of a Deep-Learning-Enabled Clinical Decision Support System for Personalized Depression Treatment Selection and Management

Prognostic and Prescriptive Predictors of Treatment Response to Adjunctive VNS Therapy in Major Depressive Disorder: A RECOVER Trial Report

Delineating the Effects of Alcohol Use on Cognition in Individuals With Neurocognitive Disorders

Treatment Use and Preference in a Diverse Sample of Women With Mood Disorders

Understanding the Characteristics and Burden of Cognitive Impairments in Schizophrenia in the US: Medical Expenditure Panel Survey

Comparative Effectiveness Research Trial for Antidepressant Incomplete and Nonresponders With Treatment Resistant Depression (ASCERTAIN-TRD): Effect of Aripiprazole or Repetitive Transcranial Magnetic Stimulation Augmentation Versus Switching to the Antidepressant Venlafaxine on Quality of Life

Levomilnacipran, but Not Duloxetine, Inhibits Serotonin and Norepinephrine Reuptake Throughout Its Therapeutic Range

Prediction of Adolescent Suicidal Events by Residual Depressive Symptoms After Intensive Treatment

Outpatient Ketamine Prescribing Practices in Psychiatry in the United States: A Nationwide Survey Study

Detecting Tardive Dyskinesia Using Video-Based Artificial Intelligence

Cognitive Behavioral Therapy for Insomnia With Prolonged Exposure Compared to Sleep Hygiene and Prolonged Exposure: A Randomized Controlled Trial

Risk of Alzheimer Disease and Vascular Dementia in Patients With Peripheral Vestibular Disorders: A Longitudinal Study of 140,726 Participants

Association Between Adult Sexual Assault and Psychiatric Disorders: Results From the National Epidemiologic Survey on Alcohol and Related Conditions-III

Postpartum Distress Among Women With and Without Attention-Deficit/Hyperactivity Disorder

Bright Light Therapy in the Morning or Midday for the Treatment of Nonseasonal Depression in Bipolar Disorder (LuBi): A Dose-Escalation Phase 1/2 Randomized Double-Blind Trial

Differentiating Subtypes of Major Depressive Disorder Using Serum Biomarkers

Using GenAI to Train Mental Health Professionals in Suicide Risk Assessment: Preliminary Findings

A Global Population-Based Study on the Association Between Ketamine and Esketamine With Suicidality Using WHO VigiBase

A Case Series of Intimate Partner Violence in Older Adults Within an Older Persons’ Mental Health Service

Exploring Vascular Endothelial Growth Factor and Other Blood-Brain Barrier Biomarkers in Cognition of First-Episode Psychosis: An Observational Study

Actigraphy-Measured Sleep/Wake Characteristics Associated With Suicidal Ideation in Older Adults Who Have Depression and High Suicide Risk

Academic Highlights

Clinical Application of Aripiprazole Monohydrate Long-Acting Injectables for the Treatment of Bipolar Type I Disorder: A Consensus Panel Report

Clinical Application of Aripiprazole Monohydrate Long-Acting Injectables for the Treatment of Schizophrenia: A Consensus Panel Report

Commentary

How Do We Get Ketamine Safety Right? Three Questions From a Clinical Service

Clinical and Practical Psychopharmacology

The Superiority of Clozapine Over Second-Generation Antipsychotics in Patients With Treatment-Resistant Schizophrenia: Room for Doubt

Schizophrenia, Antipsychotic Drugs, and Risk of Breast Cancer

A Primer on Individual Participant Data Meta-Analysis and Its Strengths and Limitations

ASCP Corner

What Clinicians Should Know About the Pragmatic Use of Xanomeline-Trospium Combination

Case Report

Worth the Weight? The Challenges of Administering the Glucagon-Like Peptide 1 Receptor Agonist Semaglutide With Long-Term Olanzapine Use in a Patient With Schizophrenia

Zuranolone for Postpartum Depression in Real-World Clinical Practice

Letter to the Editor

Suicide Risk Among Patients with Bipolar Disorder: The Role of Sleep Disruption Versus Benzodiazepine Use

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