The Journal of
Clinical Psychiatry

Volume 86 • 2025 • 3

Narrative Review

Idiopathic Hypersomnia: Recognition and Management in Psychiatric Practice

J Clin Psychiatry 2025;86(3):24nr15718

Craig Chepke, MD, DFAPA; Ruth M. Benca, MD, PhD; Andrew J. Cutler, MD; Andrew D. Krystal, MD; Nathaniel F. Watson, MD, MSc

Original Research

A Global Population-Based Study on the Association Between Ketamine and Esketamine With Suicidality Using WHO VigiBase

J Clin Psychiatry 2025;86(3):24m15534

Angela T.H. Kwan, MD(C), MSc; Moiz Lakhani, MD(C), BHSc; Joshua D. Rosenblat, MD, MSc, FRCPC; Rodrigo B. Mansur, MD, PhD; Taeho Greg Rhee, PhD; Kayla M. Teopiz, HBSc; Bing Cao, PhD; Roger Ho, MD, FRCPsych; Sabrina Wong, HBSc; Gia Han Le, HBSc; Roger S. McIntyre, MD, FRCPC

Original Research

Early Change in Depressive Symptom Severity With Naltrexone-Bupropion Combination and Its Association With Reduction in Methamphetamine Use in ADAPT-2 Trial

J Clin Psychiatry 2025;86(3):25m15825.

Manish K. Jha, MBBS; Udi E. Ghitza, PhD; Steve Shoptaw, PhD; Abu Minhajuddin, PhD; Snoben Kuruvila, MPAS; Sidarth Wakhlu, MD; Edward V. Nunes, MD; Joy Schmitz, PhD; Phillip O. Coffin, MD; Gavin Bart, MD, PhD; Thomas Carmody, PhD; Madhukar H. Trivedi, MD

$Long-Term Outcomes in Patients With Treatment-Refractory Depression Receiving Intravenous Ketamine and Intranasal Esketamine: An Observational Study$

Original Research

Long-Term Outcomes in Patients With Treatment-Refractory Depression Receiving Intravenous Ketamine and Intranasal Esketamine: An Observational Study

J Clin Psychiatry 2025;86(3):25m15831

Balwinder Singh, MD, MS; Vanessa K. Pazdernik, MS; Simon Kung, MD; Jennifer L. Vande Voort, MD

Original Research

Effect of Nature Videos on the Burden of Caregivers of Patients With Dementia

J Clin Psychiatry 2025;86(3):25m15817

Kritta Supanimitamorn, MD, FRCPsychT; Gobhathai Sittironnarit, MD, FRCPsychT; Kankamol Jaisin, MD, MSc, FRCPsychT; Naratip Sa-nguanpanich, BSc; Kitikan Thana-udom, MD, FRCPsychT

Original Research

Early Response to Ketamine for Suicidal Crisis Reduces Suicidal Events at 3 Months

J Clin Psychiatry 2025;86(3):25m15829

Martin Pastre, MD, Msc; Raphael Chancel, MD; Manon Malestroit, PhD; Philippe Courtet, MD, PhD; Emilie Olié, MD, PhD

Original Research

Efficiency and Extent of Niacin-Induced Skin Flushing Patterns in Early Stages of Psychosis

J Clin Psychiatry 2025;86(3):24m15559

TianHong Zhang, PhD; LiHua Xu, PhD; YanYan Wei, PhD; XiaoChen Tang, PhD; RanPiao Gan, MD; Dan Zhang, PhD; ZhengHui Yi, PhD; XiaoHua Liu, PhD; HaiChun Liu, PhD; ZiXuan Wang, MD; Tao Chen, PhD; Jin Gao, PhD; Qiang Hu, PhD; LingYun Zeng, PhD; ChunBo Li, PhD; JiJun Wang, PhD

Original Research

Klotho and Matrix Metalloproteinase-9 Levels and Their Association With Inhibitory Dyscontrol in Adolescents With First-Episode Major Affective Disorders

J Clin Psychiatry 2025;86(3):24m15696

Li-Chi Chen, MD; Ya-Mei Bai, MD, PhD; Shih-Jen Tsai, MD; Ju-Wei Hsu, MD; Mu-Hong Chen, MD, PhD

Original Research

Prognostic and Prescriptive Predictors of Treatment Response to Adjunctive VNS Therapy in Major Depressive Disorder: A RECOVER Trial Report

J Clin Psychiatry 2025;86(3):25m15850

Scott T. Aaronson, MD; Charles R. Conway, MD; Charles Gordon, MS; Ying-Chieh (Lisa) Lee, MS; Mark S. George, MD; John Zajecka, MD; Patricio Riva-Posse, MD; David L. Dunner, MD; Matthew Macaluso, MD; Peter B. Rosenquist, MD; Brian J. Mickey, MD; Yvette I. Sheline, MD; Vasilis C. Hristidis, MD; Hunter Brown, MSW; Christopher L. Kriedt, BSN; Quyen Tran, BS, MBA; Mark T. Bunker, PharmD; Harold A. Sackeim, PhD; A. John Rush, MD

Original Research

Actigraphy-Measured Sleep/Wake Characteristics Associated With Suicidal Ideation in Older Adults Who Have Depression and High Suicide Risk

J Clin Psychiatry 2025;86(3):24m15522

Stephen F. Smagula, PhD; Gehui Zhang, PhD; Sara Albert, MS; Sarah Lim, MD; Allison G. Harvey, PhD; Michael R. Irwin, MD; William Vaughn McCall, MD; Charles F. Reynolds III, MD; Daniel J. Buysse, MD; Robert T. Krafty, PhD

Original Research

Exploring Vascular Endothelial Growth Factor and Other Blood-Brain Barrier Biomarkers in Cognition of First-Episode Psychosis: An Observational Study

J Clin Psychiatry 2025;86(3):24m15486

Alejandro Ballesteros, MD; María Flores-Lopez, MSc; Ana M. Sánchez-Torres, PhD; Gustavo J. Gil-Berrozpe, MSc; Lucía Moreno-Izco, MSc; Ana Gavito, MSc; Antonia Serrano, MSc; Fernando Rodríguez de Fonseca, MD, PhD; Manuel J. Cuesta, MD, PhD

Original Research

A Case Series of Intimate Partner Violence in Older Adults Within an Older Persons’ Mental Health Service

J Clin Psychiatry 2025; 86(3):24m15495

Anant Sharma, BMedSc, MBBS, MMed (Psych); Sharon Reutens, MBBS, PhD, FRANZCP; Anne P. F. Wand, MBBS, PhD, FRANZCP

Original Research

Postpartum Distress Among Women With and Without Attention-Deficit/Hyperactivity Disorder

J Clin Psychiatry 2025;86(3):24m15724

Dara E. Babinski, PhD; Kirsten Riggle, MPH; Wen-Jan Tuan, PhD

Original Research

Using GenAI to Train Mental Health Professionals in Suicide Risk Assessment: Preliminary Findings

J Clin Psychiatry 2025;86(3):24m15525

Zohar Elyoseph, PhD; Inbar Levkovitch, PhD; Yuval Haber, MA; Yossi Levi-Belz, PhD

Original Research

Differentiating Subtypes of Major Depressive Disorder Using Serum Biomarkers

J Clin Psychiatry 2025;86(3):25m15828

Jae-Min Kim, MD, PhD; Hee-Ju Kang, MD, PhD; Ju-Yeon Lee, MD, PhD; Ju-Wan Kim, MD, MSc; Honey Kim, MD, MSc; Min Jhon, MD, MSc; Sung-Wan Kim, MD, PhD; Il-Seon Shin, MD, PhD

Original Research

Bright Light Therapy in the Morning or Midday for the Treatment of Nonseasonal Depression in Bipolar Disorder (LuBi): A Dose-Escalation Phase 1/2 Randomized Double-Blind Trial

J Clin Psychiatry 2025;86(3):25m15826

Pierre A. Geoffroy, MD, PhD; Sylvie Chevret, MD, PhD; Sibylle Mauries, MD; Cendrine Chaffaut, MSc; Ali Amad, MD, PhD; Frank Bellivier, MD, PhD; Victoire Benard, MD, PhD; Philippe Courtet, MD, PhD; Caroline Dubertret, MD, PhD; Philip Gorwood, MD, PhD; Nicolas Mazer, MD; Lila Mekaoui, MD; Emilie Olié, MD, PhD; Guillaume Pataud, MD; Guillaume Vaiva, MD, PhD; Michel Lejoyeux, MD, PhD; Dorothy Sit, MD, PhD; Julia Maruani, MD, MSc

Original Research

Association Between Adult Sexual Assault and Psychiatric Disorders: Results From the National Epidemiologic Survey on Alcohol and Related Conditions-III

J Clin Psychiatry 2025;86(3):24m15631

Yann Le Strat, MD, PhD; Caroline Dubertret, MD, PhD; Sarah Tebeka, MD, PhD; Domitille Tisseau, MD; Elodie-Gaëlle Ngameni, MD, PhD

Original Research

Risk of Alzheimer Disease and Vascular Dementia in Patients With Peripheral Vestibular Disorders: A Longitudinal Study of 140,726 Participants

J Clin Psychiatry 2025;86(3):24m15699

Yun-Hsuan Lin, BS; Mu-Hong Chen, MD, PhD; Shun-Chieh Yu, MD; Ya-Mei Bai, MD, PhD; Tung-Ping Su, MD; Tzeng-Ji Chen, MD, PhD; Shih-Jen Tsai, MD

Original Research

Cognitive Behavioral Therapy for Insomnia With Prolonged Exposure Compared to Sleep Hygiene and Prolonged Exposure: A Randomized Controlled Trial

J Clin Psychiatry 2025;86(3):24m15584

Peter J. Colvonen, PhD; Christopher Hunt, PhD; Jane Park, BS; Abigail C. Angkaw, PhD; Philip Gehrman, PhD; Kira Clare, BS; Sonya B. Norman, PhD

Original Research

Detecting Tardive Dyskinesia Using Video-Based Artificial Intelligence

J Clin Psychiatry 2025;86(3):25m15792

Joseph H. Friedman, MD; Anthony A. Sterns, PhD; Joel W. Hughes, PhD; Bradley Grimm, MS; Loren Larsen, MS; Fred Ma, MD, PhD; Rakesh Ranjan, MD; Carlene MacMillan, MD; Bretton H. Talbot, PhD; Owen S. Muir, MD

Original Research

Outpatient Ketamine Prescribing Practices in Psychiatry in the United States: A Nationwide Survey Study

J Clin Psychiatry 2025;86(3):25m15809

Sagar V. Parikh, MD; Rachel M. Pacilio, MD; Jamarie Geller, MD, MA

Original Research

Prediction of Adolescent Suicidal Events by Residual Depressive Symptoms After Intensive Treatment

J Clin Psychiatry 2025;86(3):24m15462

Graham J. Emslie, MD; Sunita M. Stewart, PhD; Muruga A. Loganathan, MD; Stephen Buerkert, BS; Gabriela Lange Valenga, BS

Commentary

How Do We Get Ketamine Safety Right? Three Questions From a Clinical Service

J Clin Psychiatry 2025;86(3):25com15946

Benjamin D. Brody, MD; Dennis M. Popeo, MD, MSc; Roy W. Smetana, MD, PhD; Dora Kanellopoulos, PhD

Clinical and Practical Psychopharmacology

A Primer on Individual Participant Data Meta-Analysis and Its Strengths and Limitations

J Clin Psychiatry 2025;86(3):25f16001

Chittaranjan Andrade, MD

Clinical and Practical Psychopharmacology

Schizophrenia, Antipsychotic Drugs, and Risk of Breast Cancer

J Clin Psychiatry 2025;86(3):25f15960

Chittaranjan Andrade, MD

ASCP Corner

What Clinicians Should Know About the Pragmatic Use of Xanomeline-Trospium Combination

J Clin Psychiatry 2025;86(3):25ac15945

Joseph F. Goldberg, MD; Peter J. Weiden, MD

Case Report

Zuranolone for Postpartum Depression in Real-World Clinical Practice

J Clin Psychiatry 2025;86(3):25cr15876

Maxwell Z. Price, BA; Richard L. Price, MD

Case Report

Worth the Weight? The Challenges of Administering the Glucagon-Like Peptide 1 Receptor Agonist Semaglutide With Long-Term Olanzapine Use in a Patient With Schizophrenia

J Clin Psychiatry 2025;86(3):25cr15857

Francesca L. Ricciardi, MA; Jayda L. Melnitsky, BA; Shannon B. Peleg, BA; Preetika Govil, BS; Joshua T. Kantrowitz, MD

Letter to the Editor

Suicide Risk Among Patients with Bipolar Disorder: The Role of Sleep Disruption Versus Benzodiazepine Use

J Clin Psychiatry 2025;86(3):25lr15890.

Andrew S. Tubbs, MD, PhD; Fabian-Xosé Fernandez, PhD

Volume 86 • 2025 • 3

Narrative Review

Idiopathic Hypersomnia: Recognition and Management in Psychiatric Practice

Original Research

A Global Population-Based Study on the Association Between Ketamine and Esketamine With Suicidality Using WHO VigiBase

Early Change in Depressive Symptom Severity With Naltrexone-Bupropion Combination and Its Association With Reduction in Methamphetamine Use in ADAPT-2 Trial

Long-Term Outcomes in Patients With Treatment-Refractory Depression Receiving Intravenous Ketamine and Intranasal Esketamine: An Observational Study

Effect of Nature Videos on the Burden of Caregivers of Patients With Dementia

Early Response to Ketamine for Suicidal Crisis Reduces Suicidal Events at 3 Months

Efficiency and Extent of Niacin-Induced Skin Flushing Patterns in Early Stages of Psychosis

Klotho and Matrix Metalloproteinase-9 Levels and Their Association With Inhibitory Dyscontrol in Adolescents With First-Episode Major Affective Disorders

Prognostic and Prescriptive Predictors of Treatment Response to Adjunctive VNS Therapy in Major Depressive Disorder: A RECOVER Trial Report

Actigraphy-Measured Sleep/Wake Characteristics Associated With Suicidal Ideation in Older Adults Who Have Depression and High Suicide Risk

Exploring Vascular Endothelial Growth Factor and Other Blood-Brain Barrier Biomarkers in Cognition of First-Episode Psychosis: An Observational Study

A Case Series of Intimate Partner Violence in Older Adults Within an Older Persons’ Mental Health Service

Postpartum Distress Among Women With and Without Attention-Deficit/Hyperactivity Disorder

Using GenAI to Train Mental Health Professionals in Suicide Risk Assessment: Preliminary Findings

Differentiating Subtypes of Major Depressive Disorder Using Serum Biomarkers

Bright Light Therapy in the Morning or Midday for the Treatment of Nonseasonal Depression in Bipolar Disorder (LuBi): A Dose-Escalation Phase 1/2 Randomized Double-Blind Trial

Association Between Adult Sexual Assault and Psychiatric Disorders: Results From the National Epidemiologic Survey on Alcohol and Related Conditions-III

Risk of Alzheimer Disease and Vascular Dementia in Patients With Peripheral Vestibular Disorders: A Longitudinal Study of 140,726 Participants

Cognitive Behavioral Therapy for Insomnia With Prolonged Exposure Compared to Sleep Hygiene and Prolonged Exposure: A Randomized Controlled Trial

Detecting Tardive Dyskinesia Using Video-Based Artificial Intelligence

Outpatient Ketamine Prescribing Practices in Psychiatry in the United States: A Nationwide Survey Study

Prediction of Adolescent Suicidal Events by Residual Depressive Symptoms After Intensive Treatment

Commentary

How Do We Get Ketamine Safety Right? Three Questions From a Clinical Service

Clinical and Practical Psychopharmacology

A Primer on Individual Participant Data Meta-Analysis and Its Strengths and Limitations

Schizophrenia, Antipsychotic Drugs, and Risk of Breast Cancer

ASCP Corner

What Clinicians Should Know About the Pragmatic Use of Xanomeline-Trospium Combination

Case Report

Zuranolone for Postpartum Depression in Real-World Clinical Practice

Worth the Weight? The Challenges of Administering the Glucagon-Like Peptide 1 Receptor Agonist Semaglutide With Long-Term Olanzapine Use in a Patient With Schizophrenia

Letter to the Editor

Suicide Risk Among Patients with Bipolar Disorder: The Role of Sleep Disruption Versus Benzodiazepine Use

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Volume 86 • 2025 • 3

Narrative Review

Idiopathic Hypersomnia: Recognition and Management in Psychiatric Practice

Original Research

A Global Population-Based Study on the Association Between Ketamine and Esketamine With Suicidality Using WHO VigiBase

Early Change in Depressive Symptom Severity With Naltrexone-Bupropion Combination and Its Association With Reduction in Methamphetamine Use in ADAPT-2 Trial

Long-Term Outcomes in Patients With Treatment-Refractory Depression Receiving Intravenous Ketamine and Intranasal Esketamine: An Observational Study

Effect of Nature Videos on the Burden of Caregivers of Patients With Dementia

Early Response to Ketamine for Suicidal Crisis Reduces Suicidal Events at 3 Months

Efficiency and Extent of Niacin-Induced Skin Flushing Patterns in Early Stages of Psychosis

Klotho and Matrix Metalloproteinase-9 Levels and Their Association With Inhibitory Dyscontrol in Adolescents With First-Episode Major Affective Disorders

Prognostic and Prescriptive Predictors of Treatment Response to Adjunctive VNS Therapy in Major Depressive Disorder: A RECOVER Trial Report

Actigraphy-Measured Sleep/Wake Characteristics Associated With Suicidal Ideation in Older Adults Who Have Depression and High Suicide Risk

Exploring Vascular Endothelial Growth Factor and Other Blood-Brain Barrier Biomarkers in Cognition of First-Episode Psychosis: An Observational Study

A Case Series of Intimate Partner Violence in Older Adults Within an Older Persons’ Mental Health Service

Postpartum Distress Among Women With and Without Attention-Deficit/Hyperactivity Disorder

Using GenAI to Train Mental Health Professionals in Suicide Risk Assessment: Preliminary Findings

Differentiating Subtypes of Major Depressive Disorder Using Serum Biomarkers

Bright Light Therapy in the Morning or Midday for the Treatment of Nonseasonal Depression in Bipolar Disorder (LuBi): A Dose-Escalation Phase 1/2 Randomized Double-Blind Trial

Association Between Adult Sexual Assault and Psychiatric Disorders: Results From the National Epidemiologic Survey on Alcohol and Related Conditions-III

Risk of Alzheimer Disease and Vascular Dementia in Patients With Peripheral Vestibular Disorders: A Longitudinal Study of 140,726 Participants

Cognitive Behavioral Therapy for Insomnia With Prolonged Exposure Compared to Sleep Hygiene and Prolonged Exposure: A Randomized Controlled Trial

Detecting Tardive Dyskinesia Using Video-Based Artificial Intelligence

Outpatient Ketamine Prescribing Practices in Psychiatry in the United States: A Nationwide Survey Study

Prediction of Adolescent Suicidal Events by Residual Depressive Symptoms After Intensive Treatment

Commentary

How Do We Get Ketamine Safety Right? Three Questions From a Clinical Service

Clinical and Practical Psychopharmacology

A Primer on Individual Participant Data Meta-Analysis and Its Strengths and Limitations

Schizophrenia, Antipsychotic Drugs, and Risk of Breast Cancer

ASCP Corner

What Clinicians Should Know About the Pragmatic Use of Xanomeline-Trospium Combination

Case Report

Zuranolone for Postpartum Depression in Real-World Clinical Practice

Worth the Weight? The Challenges of Administering the Glucagon-Like Peptide 1 Receptor Agonist Semaglutide With Long-Term Olanzapine Use in a Patient With Schizophrenia

Letter to the Editor

Suicide Risk Among Patients with Bipolar Disorder: The Role of Sleep Disruption Versus Benzodiazepine Use

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