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ASCP Corner

Balancing Risks: Dosing Strategies for Antidepressants Near the End of Pregnancy

Laura J. Miller, MD; Jeffrey R. Bishop, PharmD; James H. Fischer, PharmD; Stacie E. Geller, PhD; and Carol Macmillan, MD

Published: February 14, 2008

Article Abstract

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One of the most difficult balancing actsin clinical psychopharmacology practice isminimizing the risks of untreated depressionin pregnant women while also minimizingthe risks of antidepressant treatment.Major depression is estimated tooccur in 9.4% to 12.7% of pregnantwomen1 and to recur in over two thirds ofwomen who discontinue antidepressantmedication while pregnant.2 Antenatal depressivesymptoms can compromise outcomesfor women and their offspring.3

Volume: 69

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