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Letters To the Editor

Effects of the Traditional Chinese Herbal Medicine Yi-Gan San for Cholinesterase Inhibitor-Resistant Visual Hallucinations and Neuropsychiatric Symptoms in Patients With Dementia With Lewy Bodies

Koh Iwasaki, MD, PhD; Masahiro Maruyama, MD, PhD; Naoki Tomita, MD; Katsutoshi Furukawa, MD, PhD; Miyako Nemoto, MD; Hironori Fujiwara, MD, PhD; Takashi Seki, MD, PhD; Masahiko Fujii, MD, PhD; Manabu Kodama, MD, PhD; and Hiroyuki Arai, MD, PHD

Published: December 15, 2005

Article Abstract

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Sir: Dementia with Lewy bodies (DLB) is characterizedclinically by progressive and fluctuating cognitive decline, visualhallucinations, and parkinsonism.1 Some studies have reportedthat cholinesterase inhibitors are at least partiallybeneficial for treating patients with DLB.2-4 However, Shea etal.5 reported that cholinesterase inhibitors occasionally causeddeterioration of parkinsonian symptoms in patients with DLB.’ ‹

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