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Original Research

Genetic Studies of Panic Disorder: A Review

Odile A. van den Heuvel, Ben J. M. van de Wetering, Dick J. Veltman, and David L. Pauls

Published: October 31, 2000

Article Abstract

Background: A review of the studies examiningthe genetic etiology of panic disorder shows the familial natureof the disorder and demonstrates that the etiology is greatlyinfluenced by genetic factors. Strong evidence for verticaltransmission in family studies led to molecular genetic studies,of which association designs appear promising, particularly whenbased on trait markers.

Data Sources: The MEDLINE and PsycLIT databaseswere searched for all reports published between 1966 and 2000containing the keywords panic, genetic, twin, adoption,linkage, association, and QTL.

Conclusion: We conclude that the multifactorialnature of panic disorder requires a multidisciplinary approach togain insight into the determinants of the phenotype and theinteraction of environmental and genetic factors.

Volume: 61

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