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Letter to the Editor

Weight Gain, Sexual Dysfunction, and Bupropion

Michael J. Menaster, MD

Published: October 14, 2005

Article Abstract

Because this piece has no abstract, we have provided for your benefit the first 3 sentences of the full text.

Sir: In their recent (May 2005) article, Zimmerman et al.1reported that bupropion is not associated with weight gainor sexual dysfunction. I disagree with their assertion for thefollowing reasons.

Concerning weight gain, the package insert for bupropionextended-release (XL)2 states that 9% of patients treated withthe immediate-release (IR) form of bupropion gained weight,a rate higher than that found with placebo.

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Volume: 66

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