Letter to the Editor December 15, 2016

Tramadol-Induced Hypomania and Serotonin Syndrome

Prim Care Companion CNS Disord 2016;18(6):doi:10.4088/PCC.16l01975

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To the Editor: Tramadol, a centrally acting synthetic opioid analgesic, has at least 2 complementary mechanisms of action. It binds to μ-opioid receptors and is a weak inhibitor of reuptake of norepinephrine and serotonin. Tramadol shares many characteristics with venlafaxine.