Letter to the Editor August 9, 2018

Tramadol: Relieves Pain, Improves Mood, Induces Mania

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Prim Care Companion CNS Disord 2018;20(4):17l02193

Article Abstract

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To the Editor: Corticosteroids and antidepressants are known to induce manic episodes in predisposed individuals. Manic episodes in bipolar patients triggered by tramadol have also been reported.

Tramadol acts as an opiate agonist by activating the μ-opioid receptor and as a promotor of serotonin and norepinephrine activity by modulating their transport.