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Letter to the Editor

Vitamin B12 Deficiency Manifested as Mania: A Case Report

German Jorge Gomez-Bernal, MD, and Milagros Bernal-Perez, PhD

Published: June 15, 2007

Article Abstract

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Sir: Multiple psychiatric symptoms may precede perniciousanemia. Only 1 case of full manic syndrome secondary to B12deficiency has been reported.1


Case report. Ms. A was a 35-year-old woman with no personalor family history of psychiatric disorders, who was admittedto the hospital in February of 2005 with a 3-weekhistory of episodes of manic symptoms of several hours’ duration,including grandiosity, hyperactivity, sexual indiscretion,hyperphagia, irritable mood, reckless behavior, flight of ideas,and overbearing manner.

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Volume: 9

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