The COVID-19 pandemic has affected the daily life of millions worldwide, with still unclear effects on mental health. This study examined patterns in pediatric psychiatric visits to hospital emergency departments in Italy during the pandemic lockdown.
Here, the authors provide primary care providers a foundation for understanding pediatric hyperkinetic movement disorders, including tips on creation of a differential diagnosis, assessment of risk factors, and guidance on management strategies.
Psychiatric symptoms in empty sella are uncommon, but empty sella syndrome has been reported to be present along with psychosis. This report presents a case of Wilson’s disease with psychotic presentation and empty sella syndrome in an adolescent.
Electroconvulsive therapy (ECT) use in children and adolescents is much less common than in adults, and the evidence base for its use in youth is limited. This study reports outcomes of a cohort of youth treated with ECT at an academic medical center.
Have you ever seen a toddler who ingested a toxic agent, been uncertain about the dangers of psychotropics in children, or wondered if antidotes exist to reverse such toxidromes? Read this Rounds in the General Hospital article to find out more.
Could methylphenidate improve misophonia associated with worsening distractibility? Read this report of an adolescent male with inattention, distractibility, and negative emotional and autonomic response to specific sound stimulus to find out more.
Cyberbullying has received much mainstream media attention, but controversy exists regarding its prevalence. This study examined the prevalence of cyberbullying in adolescent psychiatric inpatients and its relation to potential risk factors.
Does neuroimaging, particularly computed tomography and magnetic resonance imaging, have diagnostic value in young patients with first-episode psychosis? Read the results of this retrospective cohort study to learn more.
Experiential avoidance (EA), a multifaceted transdiagnostic construct implicated in major MDD and GAD, has received little study in adolescence. Read this article to learn about EA's role in MDD and GAD symptom trajectories in adolescents.
Psychotic-like experiences in adolescence can be predictors of developing subsequent psychosis. This longitudinal study examined the likelihood of this progression as well as other factors that contribute to this risk of developing a psychiatric disorder.
Baclofen, a French Exception, Seriously Harms Alcohol Use Disorder Patients Without Benefit
To the Editor: Dr Andrade’s analysis of the Bacloville trial in a recent Clinical and Practical Psychopharmacology column, in which he concluded that “individualized treatment with high-dose baclofen (30-300 mg/d) may be a useful second-line approach in heavy drinkers” and that “baclofen may be particularly useful in patients with liver disease,” deserves comment.1
First, Andrade failed to recall that the first pivotal trial of baclofen, ALPADIR (NCT01738282; 320 patients, as with Bacloville), was negative (see Braillon et al2).
Second, Dr Andrade should have warned readers that Bacloville’s results are most questionable, lacking robustness. Although he cited us,3 he overlooked the evidence we provided indicating that the Bacloville article4 was published without acknowledging major changes to the initial protocol, affecting the primary outcome. Coincidentally (although as skeptics, we do not believe in coincidence), the initial statistical team was changed when data were sold to the French pharmaceutical company applying for the marketing authorization in France. As Ronald H. Coase warned, “If you torture the data long enough, it will confess.”